Fig. 1. (A) Low density lipoprotein receptor (LDLR) consists of a cytosolic domain, EGF-like domain, β-propeller domain and several LA modules (LA module reproduced from PDB 1AJJ, ref. 32). (B) Overview of LA modules that were chemically synthesized in this work. (C) Comparison of ylide masked aspartic acid building blocks with the typically used aspartic acid building block Fmoc-Asp(OtBu)-OH.
