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. 2023 Mar 22;14:1138078. doi: 10.3389/fendo.2023.1138078

Figure 7.

Figure 7

The lipid mechanism of NAFLD and anti-lipid accumulation mechanism of VD associated with PPARa pathway. Patients with NAFLD exhibited higher BMI, WC, SBP, DBP, AST, ALT, GGT, ALP, INS, GLU, HOMA-IR, TC, TG, LDL-C and lower HDL-C. The increased lipid oxidation and lipid uptake related proteins by VD treatment were inhibited after the application of MK886 in vivo and in vitro.