Table 2.
The Ongoing Clinical Trials of MSCs Therapy in KD.
| No. | Estimated enrollment | Phase | MSCs source | Status | Sponsor | Clinical trial ID |
|---|---|---|---|---|---|---|
| AKI | ||||||
| 1 | 80 | I/II | UCMSCs | Not recruiting | Chinese PLA General Hospital, China | NCT04194671 |
| 2 | 15 | I | ADMSCs | Recruiting | Tambi Jarmi, USA | NCT04388761 |
| 3 | 15 | I | BMMSCs | Completed | AlloCure Inc., USA | NCT00733876 |
| 4 | 24 | I/II | MSCs | Not recruiting | Sentien Biotechnologies, Inc. | NCT03015623 |
| CKD | ||||||
| 1 | 7 | I | BMMSCs | Completed | Royan Institute, Iran | NCT02195323 |
| 2 | 44 | I/II | UCMSCs | Recruiting | Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, China | NCT05512988 |
| 3 | 20 | I | BMMSCs | Recruiting | Mayo Clinic Florida, USA | NCT05362786 |
| 4 | 31 | I/II | ADMSCs | Recruiting | Bangladesh Laser & Cell Surgery Institute & Hospital, Bangladesh | NCT03939741 |
| 5 | 116 | II | UCMSCs | Unknown | Zhujiang Hospital, China | NCT02966717 |
| 6 | 40 | I | ADMSCs | Recruiting | Mayo Clinic Florida, USA | NCT04869761 |
| 7 | 6 | I | BMMSCs | Completed | Royan Institute, Iran | NCT02166489 |
| 8 | 10 | I | BMMSCs | Recruiting | Pharmicell Co., Ltd., Korea | NCT05042206 |
| 9 | 20 | I | UCMSCs | Recruiting | The Foundation for Orthopaedics and Regenerative Medicine, Antigua, and Barbuda | NCT05018845 |
| 10 | 7 | I | BMMSCs | Completed | Royan Institute, Iran | NCT02195323 |
| 11 | 20 | I/II | MSCs | Unknown | Fuzhou General Hospital, China | NCT00659620 |
| 12 | 30 | II | ADMSCs | Recruiting | Mayo Clinic in Rochester, USA | NCT03325322 |
| 13 | 31 | I/II | ADMSCs | Recruiting | Bangladesh Laser & Cell Surgery Institute & Hospital, Bangladesh | NCT03939741 |
| 14 | 42 | I | ADMSCs | Completed | University of Alabama, USA | NCT02266394 |
| 15 | 60 | Urinary MSCs | Not recruiting | Hospices Civils de Lyon, France | NCT04998461 | |
| 16 | 100 | Not applicable | ADMSCs | Unknown | The Affiliated Hospital of Xuzhou Medical University, China | NCT03321942 |
| 17 | 30 | I/II | MSCs | Unknown | Nanjing Medical University, China | NCT03460223 |
| 18 | 100 | Not applicable | ADMSCs | Unknown | The Affiliated Hospital of Xuzhou Medical University, China | NCT03321942 |
| DN | ||||||
| 1 | 30 | I | ADMSCs | Recruiting | Mayo Clinic in Rochester, USA | NCT03840343 |
| 2 | 54 | I/II | UCMSCs | Unknown | Shanghai East Hospital, China | NCT04216849 |
| 3 | 15 | Early I | UCMSCs | Recruiting | Yan’an Affiliated Hospital of Kunming Medical University, China | NCT04125329 |
| 4 | 38 | Not applicable | UCMSCs | Unknown | Renmin Hospital of Wuhan University, China | NCT04562025 |
| 5 | 48 | I/II | BMMSCs | Recruiting | Mario Negri Institute for Pharmacological Research, Ireland | NCT02585622 |
| 6 | 20 | I/II | Wharton Jelly MSCs | Unknown | University of Jordan, Jordan | NCT03288571 |
| 7 | 15 | I | ADMSCs | Recruiting | Albert Hakaim, USA | NCT04392206 |
| Lupus nephritis | ||||||
| 1 | 16 | I | Human amniotic MSCs | Completed | Yan’an Affiliated Hospital of Kunming Medical University, China | NCT04318600 |
| 2 | 230 | II | UCMSCs | Unknown | The Affiliated Drum Tower Hospital of Nanjing University Medical School, China | NCT03580291 |
| 3 | 20 | I/II | BMMSCs | Unknown | Fuzhou General Hospital, China | NCT00659217 |
| 4 | 30 | Not applicable | UCMSCs | Unknown | The First Affiliated Hospital of Dalian Medical University, China | NCT03458156 |
| 5 | 36 | II | BMMSCs | Not recruiting | Hanyang University Hospital, Korea | NCT03673748 |
| 6 | 7 | I | BMMSCs | Completed | Corestem, Inc., Korea | NCT03174587 |
| 7 | 25 | II | UCMSCs | Unknown | Second Affiliated Hospital & SLE Research Centre, Kunming Medical University, China | NCT01539902 |
| 8 | 7 | I | BMMSCs | Completed | Hanyang university hospital, Korea | NCT03174587 |
ADMSCs: adipose-derived mesenchymal stem cells; AKI: acute kidney injury; BMMSCs: bone marrow mesenchymal stem cells; CKD: chronic kidney disease; DN: diabetic nephropathy; KD: kidney disease; MSCs: mesenchymal stem cells; UCMSCs: umbilical cord mesenchymal stem cells.