Table 1.
Differentially exon usages genes in mouse models used in this study. Number of genes with differential exon usage in each mouse model compared to age and sex-matched B6 control mice. Number in parentheses shows the overlap between genes with DEU and differentially expressed genes (DEGs)
| MOUSE MODELS | AGE (in months) | Genes with differential exon usage (DEU) | |
|---|---|---|---|
| MALE | FEMALE | ||
| APOE4 | 4 | 40 (0) | 22 (0) |
| 8 | 69 (3) | 49 (1) | |
| 12 | 4 (1) | 6 (1) | |
| 24 | 12 (0) | 12 (0) | |
| Trem2*R47H | 4 | 9 (0) | 41 (0) |
| 8 | 35 (0) | 36 (0) | |
| 12 | 207 (8) | 273 (9) | |
| 24 | 23 (0) | 27 (2) | |
| APOE4.Trem2*R47H | 4 | 77 (0) | 11 (0) |
| 8 | 46 (0) | 13(0) | |
| 12 | 48 (1) | 56 (1) | |
| 24 | 20 (0) | 31 (2) | |