Table 2.

Differentially spliced genes in Trem2 KO mice. Number of genes showing differential exon usage in Trem2 KO male mice compared to respective B6 control mice in Cortex and hippocampus brain regions. Overlap between DEU genes in Trem2 KO male mice and Trem2*R47H male mice at 4, 8, 12, and 24 months. Significance of overlaps were computed using hypergeometric test

Brain Tissue	Age (in months)	DEU Genes in Trem2.KO mice	Overlapped with DEU genes in Trem2.R47H mice
			12 months Trem2.R47H	4 mo. Trem2.R47H	8 mo. Trem2.R47H	24 mo. Trem2.R47H
Cortex	4	734	38 (p = 4.29E-13)	1 (p = 0.36)	5 (p = 0.02)	2 (p = 0.28)
	8	874	34 (p = 1.51E-08)	2 (p = 0.09)	3 (p = 0.30)	1 (p = 0.72)
Hippocampus	4	782	26 (p = 1.50E-05)	1 (p = 0.37)	4 (p = 0.09)	4 (p = 0.02)
	8	723	30 (p = 4.29E-13)	2 (p = 0.07)	2 (p = 0.48)	1 (p = 0.65)