Table 4.

Differentially isoform usages genes identified in mouse models using IsoformSwitchAnalyzerR (ISAR). Number of genes showing differential isoform (or transcript) usage in each mouse model compared to age and sex-matched B6 control mice

Mouse Models	Age	Sex	All Isoform with differential usage
			nrIsoforms	nrSwitches	nrGenes
APOE4	4	Male	66	81	58
	4	Female	77	88	63
	8	Male	54	66	49
	8	Female	39	51	35
	12	Male	62	86	57
	12	Female	45	65	40
	24	Male	28	34	24
	24	Female	36	39	27
Trem2*R47H	4	Male	54	60	47
	4	Female	36	41	31
	8	Male	54	65	45
	8	Female	56	61	50
	12	Male	273	256	215
	12	Female	94	91	77
	24	Male	21	24	17
	24	Female	276	267	218
APOE4.Trem2*R47H	4	Male	88	106	77
	4	Female	39	46	31
	8	Male	62	72	55
	8	Female	46	50	39
	12	Male	41	49	34
	12	Female	78	99	72
	24	Male	18	23	15
	24	Female	41	44	34