Table 6.
Summary of differentially spliced genes identified in multiple human AD splicing studies and overlap with mouse models. Number of differentially spliced genes identified in splicing analyses of human AD cohort in multiple studies and overlap with differentially spliced genes in mouse models were identified using differential isoform usage approach (IsoformSwitchAnalyzerR). Control-AsymAD represents comparison between asymptomatic AD cases and controls. AsymAD-AD represents comparison between AD cases and asymptomatic AD cases. Control-AD represents comparison between AD cases and controls
| Differentially Spliced Genes |
Overlap with 12 mo. Trem2 male mice (215 DTU) |
Overlap across all mouse models (1410 DTU) |
|
|---|---|---|---|
| ROSMAP | 67 | 1 (p = 0.58) | 4 (p = 0.83) |
|
TMT Proteomic Study (Control-AsymAD) |
155 | 7 (p = 0.004) | 16 (p = 0.23) |
| TMT Proteomic Study (Asym-AD) | 291 | 7 (p = 0.08) | 16 (p = 0.97) |
|
TMT Proteomic Study (Control-AD) |
237 | 7 (p = 0.03) | 17 (p = 0.79) |
| Emory/Kentucky | 536 | 15 (p = 0.003) | 44 (p = 0.6) |