Table 7.
Mouse genes identified either in both approaches/multiple human AD splicing studies: Genes that are either identified as differentially spliced using both DEXSeq and ISAR tools and further reported to be differentially spliced in at-least one human AD splicing study or reported to be differentially spliced in multiple human AD splicing studies and also identified by any one of these tools in 12 months old Trem2*R47H male mice
| Splicing Analysis Tools | Human AD splicing Studies | |||||
|---|---|---|---|---|---|---|
| SYMBOL | ENSEMBL | DEXSeq | ISAR | ROSMAP | TMT-Proteomics | Emory/Kentucky |
| Ppp1r9b | ENSMUSG00000038976 | Y | Y | - | Y | - |
| Celf4 | ENSMUSG00000024268 | Y | Y | - | - | Y |
| Fars2 | ENSMUSG00000021420 | Y | Y | - | - | Y |
| Macf1 | ENSMUSG00000028649 | Y | N | Y | Y | - |
| Ppp3ca | ENSMUSG00000028161 | Y | N | Y | Y | Y |
| Eno2 | ENSMUSG00000004267 | Y | N | Y | Y | Y |
| Stxbp1 | ENSMUSG00000026797 | Y | N | - | Y | Y |
| Kif21a | ENSMUSG00000022629 | Y | N | Y | Y | - |
| Eiftud2 | ENSMUSG00000020929 | Y | N | - | Y | Y |
| Pfn2 | ENSMUSG00000027805 | N | Y | - | Y | Y |
| Psmd2 | ENSMUSG00000006998 | N | Y | - | Y | Y |