TABLE 1.

Summary of PET tracers most employed/investigated for breast imaging, with corresponding biological properties and clinical applications

Tracer	Full Name	Detected Biological Processes	Clinical Use	FDA Approval
18F‐FDG	2‐deoxy‐2‐18Ffluoroglucose	GLUT‐1 upregulation Hexokinase activity	Staging Response assessment Diagnosis	Yes
18F‐NaF	Fluorine 18–Sodium Fluoride	Hydroxyapatite exposure during bone remodeling	Detection of bone metastasis	Yes
18F‐FES	16α‐18F‐fluoroestradiol	Estrogen receptor expression	Staging Diagnosis ER+ BC	Yes
89Zr‐trastuzumab	89Zr‐trastuzumab	HER2 expression	Diagnosis HER+ BC Assessment HER2 status	No
11C‐choline and 18F‐choline	N‐[11C] methylcholine 18F‐Fluoroethylcholine	Cell membrane synthesis	Staging Response assessment Diagnosis	Yes
18F‐FLT	3‐deoxy‐3‐[18F] Fluorothymidine	DNA synthesis	Response assessment	No
68Ga‐FAPI‐46	68Ga‐conjugated fibroblast activation protein inhibitor	FAP detection‐ modulation of tumor microenvironment	Diagnosis Staging	No