Table 1.

ICOR runtime comparable to the BFC, HFC, and URC approaches and significantly faster than ERC approach

	Average Time (n. seq = 40) (n. trials = 3)	Time Per Seq	Time Per Codon	Time per NT
ERC	275,587% (749597 ms) (750.517 s, 749.821 s, 748.455 s)	18,739.9 ms	1332.50 ms	444.166 ms
ICOR	288% (782 ms) (0.772 s, 0.807 s, 0.766 s)	19.5 ms	1.39 ms	0.463 ms
BFC	283% (771 ms) (0.761 s, 0.764 s, 0.787 s)	19.3 ms	1.37 ms	0.456 ms
HFC	84% (229 ms) (0.233 s, 0.226 s, 0.228 s)	5.7 ms	0.40 ms	0.136 ms
URC	100% (272 ms) (0.271 s, 0.274 s, 0.272 s)	6.8 ms	0.48 ms	0.161 ms

Three trials were conducted with the score being an average of these three times measured to the third significant figure in milliseconds

Optimization run time is displayed with a normalized percentage to the URC approach because it represents the most naïve codon selection