Table 2.

Summary of metadata for farm and best BLAST hit NCBI plasmids with high similarity (≥ 95% identity and ≥ 90% alignment coverage) to a clinical plasmid. Only NCBI plasmids from environmental sources were included. The asterisk for the IncFII(S) plasmid indicates an exception where the pMLST genes were identical between the clinical and farm plasmids, but the percentage of shared gene cargo was less than 40%. Here, phylogenetic neighborhood refers to all NCBI Pathogen Detection isolates within 1000 core gene alleles of the clinical clade

Plasmid type	Number of isolates with plasmid (clinical, Holtville, Bakersfield)			Number of highly similar plasmids (clinical, Holtville, Bakersfield)			Number of best hits in NCBI Pathogen and Nucleotide databases	Geographic extent of NCBI best hits	Environmental isolation sources of NCBI best hits	Temporal range of NCBI best hits	Bacterial host range (genera) of NCBI best hits
IncFII(S)*	1728	3	7	1728	3*	7*	30	United States, Mexico	River water, soil, almonds, pistachios, chicken	2010 to 2020	Salmonella
IncI1-I(Gamma)	27	13	3	10	1	1	50	United States, South Korea, Canada, United Kingdom, Denmark, Switzerland	Cow, sheep, dog, pig, chicken, catfish, horse, iguana, lettuce, soil	2002 to 2022	Escherichia, Salmonella, Shigella
ColpVC	12	3	0	1	4	0	100	United States, Canada	Chicken, turkey, pig	2007 to 2020	Salmonella
Col440I	3	60	8	1	4	2	19	United States, Germany, Mexico, Venezuela, Ecuador	Chicken, cow, pig, papaya, river water	2013 to 2020	Escherichia, Salmonella
Unclassified	373	235	42	2	5	0	12	United States, Australia, United Kingdom, India, Japan	Dog, cow, pig, chicken, wastewater	2014 to 2021	Escherichia, Salmonella, Klebsiella