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. Author manuscript; available in PMC: 2023 Apr 5.
Published in final edited form as: Cell Rep. 2022 Jul 12;40(2):111076. doi: 10.1016/j.celrep.2022.111076

Figure 6: Stimulation of macrophages with LPS leads to consistent modeling results.

Figure 6:

A. Schematic of SDTF activation in response to TNF or LPS. TNF stimulation results in NFκB activity, while LPS stimulation results in both NFκB and IRF activity. B. Top: Experimental and simulated nucleosome counts after LPS stimulation, for NFκB-associated nucleosome locations after 0hrs and 4hrs (n=1 for each timepoint). Bottom: Analogous counts for IRF-associated nucleosome locations (n=1 for each timepoint). C. Eviction Probability Profiles associated with LPS-induced NFκB activity, using the same model parameters as the TNF-induced data (green) and direct fit (blue). D. Eviction Probability Profiles associated with LPS-induced IRF3 activity. *: All the parameters are the same as the fitted parameters with the TNF data (Figure 4) except for the SDTF unbinding fraction, BF. (See also Figure S5).