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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2023 Jan 29;176:84–96. doi: 10.1016/j.yjmcc.2023.01.010

Figure 6. Cardiac hemodynamic function and reserve of WT and TnI S23/24A mice following TAC.

Figure 6.

In vivo left ventricular pressure-volume hemodynamic measurements of WT TAC (black circle) and S23/24A TAC (grey triangle) mice at 12 weeks after TAC for (A) maximal diastolic volume and (B) cardiac output. n = 6 mice for WT TAC and n = 6 mice for S23/24A TAC. *P<0.05, WT TAC versus S23/24A TAC by unpaired t test. Hemodynamic measurements upon increasing heart rate from 360 to 540 beats per minute for (C) dP/dtmax, (D) dP/dtmin, (E) maximal diastolic volume and (F) cardiac output. n = 5-6 mice at each heart rate for WT TAC and n = 3-7 mice at each heart rate for TnI S23/24A TAC. *P<0.05, WT TAC versus S23/24A by two-way analysis of variance. Error bars are standard error of the mean.