Table 3.
Association between the relative expression of each SRLs response marker and different tumor characteristics.
| Gene | Relative expression mean ± SE | P-value | |
|---|---|---|---|
| TUMOR SIZE | |||
| < 2cm Ø | > 2cm Ø | ||
| n = 18 | n = 48 | ||
| SSTR2 | 0.144 ± 0.049 | 0.119 ± 0.034 | 0.660 |
| SSTR3 | 0.621 ± 0.372 | 0.571± 0.129 | 0.911 |
| SSTR5 | 0.258 ± 0.229 | 0.007 ± 0.004 | 0.288 |
| DRD2 short isoform | 2.706 ± 0.928 | 1.434 ± 0.171 | 0.096 |
| DRD2 long isoform | 2.908 ± 0.738 | 1.692 ± 0.170 | 0.046 |
| ARRB1 | 0.845 ± 0.211 | 0.743 ± 0.113 | 0.716 |
| PLAGL1 | 0.578 ± 0.181 | 0.498 ± 0.193 | 0.752 |
| PEBP1 | 18.016 ± 1.411 | 16.920 ± 1.139 | 0.577 |
| Ki-67 | 0.034 ± 0.009 | 0.060 ± 0.016 | 0.081 |
| AIP | 1.913 ± 0.017 | 2.066 ± 0.097 | 0.398 |
| IN1-GHRL | 0.080 ± 0.057 | 0.024 ± 0.002 | 0.348 |
| KLK10 | 0.010 ± 0.007 | 0.017 ± 0.004 | 0.413 |
| GHRL | 0.055 ± 0.017 | 0.032 ± 0.005 | 0.232 |
| EXTRASELLAR GROWTH | |||
| NO | YES | ||
| n = 11 | n = 60 | ||
| SSTR2 | 0.054 ± 0.016 | 0.132 ± 0.031 | 0.031 |
| SSTR3 | 0.454 ± 0.092 | 0.611± 0.152 | 0.379 |
| SSTR5 | 0.010 ± 0.009 | 0.083 ± 0.070 | 0.306 |
| DRD2 short isoform | 1.683 ± 0.360 | 1.850 ± 0.322 | 0.731 |
| DRD2 long isoform | 2.212 ± 0.459 | 2.107 ± 0.459 | 0.848 |
| ARRB1 | 0.605 ± 0.090 | 0.786 ± 0.111 | 0.209 |
| PLAGL1 | 0.412 ± 0.235 | 0.500 ± 0.160 | 0.760 |
| PEBP1 | 14.673 ± 1.372 | 17.977 ± 1.026 | 0.033 |
| Ki-67 | 0.028 ± 0.007 | 0.054 ± 0.013 | 0.042 |
| AIP | 2.041 ± 0.145 | 2.050 ± 0.088 | 0.959 |
| IN1-GHRL | 0.025 ± 0.005 | 0.041 ± 0.018 | 0.365 |
| KLK10 | 0.005 ± 0.001 | 0.017 ± 0.004 | 0.008 |
| GHRL | 0.029 ± 0.008 | 0.039 ± 0.007 | 0.347 |
| SINUS INVASION | |||
| NO | YES | ||
| n = 33 | n = 34 | ||
| SSTR2 | 0.115 ± 0.038 | 0.133 ± 0.039 | 0.748 |
| SSTR3 | 0.523 ± 0.198 | 0.672 ± 0.176 | 0.576 |
| SSTR5 | 0.135 ± 0.122 | 0.012 ± 0.006 | 0.317 |
| DRD2 short isoform | 1.967 ± 0.516 | 1.585 ± 0.214 | 0.497 |
| DRD2 long isoform | 2.292 ± 0.416 | 1.796 ± 0.218 | 0.295 |
| ARRB1 | 0.783 ± 0.155 | 0.706 ± 0.110 | 0.686 |
| PLAGL1 | 0.561 ± 0.230 | 0.425 ± 0.176 | 0.642 |
| PEBP1 | 17.495 ± 1.484 | 16.523 ± 0.978 | 0.587 |
| Ki-67 | 0.040 ± 0.015 | 0.059 ± 0.018 | 0.422 |
| AIP | 2.141 ± 0.125 | 1.941 ± 0.094 | 0.207 |
| IN1-GHRL | 0.054 ± 0.030 | 0.023 ± 0.002 | 0.319 |
| KLK10 | 0.011 ± 0.004 | 0.020 ± 0.006 | 0.194 |
| GHRL | 0.031 ± 0.008 | 0.038 ± 0.007 | 0.475 |
| PRESURGICAL HEADACHE | |||
| NO | YES | ||
| n = 41 | n = 31 | ||
| SSTR2 | 0.094 ± 0.024 | 0.147 ± 0.051 | 0.350 |
| SSTR3 | 0.468 ± 0.076 | 0.731 ± 0.273 | 0.360 |
| SSTR5 | 0.010 ± 0.004 | 0.148 ± 0.133 | 0.307 |
| DRD2 short isoform | 1.958 ± 0.231 | 1.676 ± 0.533 | 0.641 |
| DRD2 long isoform | 2.385 ± 0.275 | 1.816 ± 0.424 | 0.265 |
| ARRB1 | 0.590 ± 0.067 | 0.975 ± 0.189 | 0.063 |
| PLAGL1 | 0.367 ± 0.257 | 0.644 ± 0.257 | 0.349 |
| PEBP1 | 17.877 ± 1.098 | 16.731 ± 1.455 | 0.532 |
| Ki-67 | 0.036 ± 0.008 | 0.068 ± 0.023 | 0.203 |
| AIP | 2.047 ± 0.093 | 2.042 ± 0.127 | 0.974 |
| IN1-GHRL | 0.023 ± 0.002 | 0.059 ± 0.033 | 0.289 |
| KLK10 | 0.012 ± 0.004 | 0.017 ± 0.005 | 0.480 |
| GHRL | 0.036 ± 0.007 | 0.059 ± 0.009 | 0.784 |
| PRESURGICAL HYPOPITUITARISM | |||
| NO | YES | ||
| n = 39 | n = 33 | ||
| SSTR2 | 0.155 ± 0.048 | 0.087 ± 0.019 | 0.201 |
| SSTR3 | 0.695 ± 0.090 | 0.454 ± 0.090 | 0.347 |
| SSTR5 | 0.133 ± 0.004 | 0.006 ± 0.004 | 0.276 |
| DRD2 short isoform | 2.162 ± 0.489 | 1.547 ± 0.247 | 0.267 |
| DRD2 long isoform | 2.338 ± 0.414 | 1.983 ± 0.271 | 0.476 |
| ARRB1 | 0.606 ± 0.086 | 0.571 ± 0.175 | 0.181 |
| PLAGL1 | 0.482 ± 0.114 | 0.511 ± 0.280 | 0.924 |
| PEBP1 | 18.383 ± 1.269 | 16.528 ± 1.360 | 0.322 |
| Ki-67 | 0.042 ± 0.016 | 0.057 ± 0.018 | 0.526 |
| AIP | 2.084 ± 0.119 | 2.001 ± 0.104 | 0.599 |
| IN1-GHRL | 0.051 ± 0.029 | 0.026 ± 0.003 | 0.390 |
| KLK10 | 0.011 ± 0.004 | 0.019 ± 0.006 | 0.256 |
| GHRL | 0.035 ± 0.008 | 0.036 ± 0.007 | 0.961 |
| VISUAL ALTERATIONS | |||
| NO | YES | ||
| n = 43 | n = 29 | ||
| SSTR2 | 0.134 ± 0.048 | 0.107 ± 0.030 | 0.635 |
| SSTR3 | 0.343 ± 0.075 | 0.724 ± 0.193 | 0.071 |
| SSTR5 | 0.013 ± 0.006 | 0.104 ± 0.092 | 0.328 |
| DRD2 short isoform | 1.642 ± 0.294 | 1.953 ± 0.396 | 0.531 |
| DRD2 long isoform | 2.061 ± 0.382 | 2.187 ± 0.313 | 0.799 |
| ARRB1 | 0.662 ± 0.146 | 0.812 ± 0.119 | 0.428 |
| PLAGL1 | 0.671 ± 0.289 | 0.375 ± 0.132 | 0.359 |
| PEBP1 | 17.078 ± 1.162 | 17.566 ± 1.234 | 0.774 |
| Ki-67 | 0.045 ± 0.019 | 0.052 ± 0.014 | 0.774 |
| AIP | 1.932 ± 0.110 | 2.113 ± 0.101 | 0.228 |
| IN1-GHRL | 0.021 ± 0.002 | 0.048 ± 0.023 | 0.249 |
| KLK10 | 0.011 ± 0.006 | 0.017 ± 0.004 | 0.409 |
| GHRL | 0.039 ± 0.008 | 0.036 ± 0.007 | 0.828 |
P-value was calculated for each tumor characteristic (Student's t test or Mann–Whitney U test, as appropriate). Significant p-values are shown in bold. SE, Standard Error.