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. 2023 Mar 21;62:102687. doi: 10.1016/j.redox.2023.102687

Fig. 7.

Fig. 7

Silencing Drp1 expression by siRNA or Mdivi-1 treatment rescues ph-IOP-induced RGC PANoptosis in vivo.

A: After silencing Drp1 expression by siRNA, HE was used to observe the retinal morphology and the number of cells in the RGC layer. Scale bar = 50 μm; B: After silencing Drp1 expression by siRNA, RBPMS-positive cells in whole mounted retinas were assessed by observing flat-mounted retinas; Scale bar = 50 μm; C: Quantification of the number of cells in the GCL of each group(n = 9); D: Quantification of RGC cell density in each group(n = 9); E: After silencing Drp1 expression by siRNA, Western blot used to detected PANoptosis-related proteins; F–M: Western blot results were quantified(n = 9); N:After Mdivi-1 treatment, Western blot was used to detect PANoptosis-related proteins; O–W: Western blot results were quantified(n = 9). Values are expressed as the mean ± SD. One-way ANOVA was followed by Dunnett's test. *P < 0.05, **P < 0.01, ***P < 0.001and****P < 0.0001 vs ph-IOP.