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. 2023 Mar 21;62:102687. doi: 10.1016/j.redox.2023.102687

Fig. 8.

Fig. 8

Silencing Drp1 expression by siRNA or Mdivi-1 treatment rescues ph-IOP-induced RGC PANoptosis in vivo.

A: After si-Drp1 or Mdivi-1 treatment, retinal immunofluorescence staining detected cleaved-caspase1 expression levels, Scale bar = 10 μm(n = 9); B: After si-Drp1or Mdivi-1 treatment, immunofluorescence used to detect cleaved-caspase3 expression levels, Scale bar = 10 μm(n = 9); C: After si-Drp1 or Mdivi-1 treatment, immunofluorescence used to detect p-MLKL expression levels, Scale bar = 10 μm (n = 9). NC: negative control. Values are expressed as the mean ± SD. One-way ANOVA was followed by Dunnett's test. *P < 0.05, **P < 0.01, ***P < 0.001and****P < 0.0001 vs ph-IOP.