Comparison 2. Opioids versus oral sweet solution or non‐pharmacological intervention.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 CRIES	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1.1 Opioids vs facilitated tucking	1	100	Mean Difference (IV, Fixed, 95% CI)	‐4.62 [‐6.38, ‐2.86]
2.1.2 Opioids vs sensorial stimulation	1	100	Mean Difference (IV, Fixed, 95% CI)	0.32 [‐1.13, 1.77]