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. 2022 Oct 11;18(7):1591–1600. doi: 10.4103/1673-5374.355979

Additional Table 5.

GO cellular component analysis of differentially expressed proteins

Total
Term Candidat Term Total
Candidate e Gene Gene Gene
GO C Term ID GO_C Term Desc GO C Term Level1 GO C Term Level2 Gene Num Num Num Num Rich Ratio P value Q value
GO:0005739 mitochondrion cellular_component organelle 64 255 1926 25187 0.033229 9.47E-18 3.36E-15
GO:0043209 myelin sheath cellular_component cell part 20 255 246 25187 0.081301 9.73E-13 1.73E-10
GO:0005743 mitochondrial inner membrane cellular_component organelle 28 255 565 25187 0.049558 5.14E-12 6.08E-10
GO:0070062 extracellular exosome cellular_component organelle 73 255 3513 25187 0.02078 7.01E-10 6.22E-08
GO:0008021 synaptic vesicle cellular_component organelle 14 255 162 25187 0.08642 1.21E-09 8.61E-08
GO:0016020 membrane cellular_component membrane 141 255 9539 25187 0.014781 1.08E-08 6.37E-07
GO:0005741 mitochondrial outer membrane cellular_component organelle 15 255 244 25187 0.061475 3.24E-08 1.64E-06
GO:0030667 secretory granule membrane cellular_component organelle 10 255 144 25187 0.069444 2.22E-06 9.85E-05
GO:0070821 tertiary granule membrane cellular_component organelle 8 255 97 25187 0.082474 6.57E-06 2.59E-04
GO:0070469 respiratory chain cellular_component membrane 6 255 61 25187 0.098361 3.54E-05 0.001256
GO:0005751 mitochondrial respiratory chain cellular_component organelle 4 255 22 25187 0.181818 6.50E-05 0.002099
GO:0005737 cytoplasm cellular_component cell part 115 255 8450 25187 0.013609 7.81E-05 0.002309
GO:0005886 plasma membrane cellular_component membrane 91 255 6315 25187 0.01441 9.80E-05 0.002676
GO:0061617 MICOS complex cellular_component organelle 255 10 25187 0.3 1.17E-04 0.002961
GO:0101003 ficolin-1-rich granule membrane cellular_component organelle 6 255 78 25187 0.076923 1.42E-04 0.003356
GO:0005829 cytosol cellular_component cell part 102 255 7429 25187 0.01373 2.03E-04 0.004498
GO:0005747 mitochondrial respiratory chain cellular_component organelle 5 255 60 25187 0.083333 3.55E-04 0.007407
GO:0005759 mitochondrial matrix enclosed lumen cellular_component membrane- 14 255 481 25187 0.029106 4.27E-04 0.008414
GO:0046930 pore complex cellular_component membrane 3 255 18 25187 0.166667 7.48E-04 0.013972
GO:0009986 cell surface cellular_component cell 20 255 900 25187 0.022222 9.01E-04 0.015988
GO:0000275 mitochondrial proton- transporting ATP synthase complex, catalytic core F(1) cellular_component organelle 2 255 5 25187 0.4 0.001001 0.016916
GO:0048471 perinuclear region of cytoplasm cellular_component cell part 20 255 914 25187 0.021882 0.001085 0.01751
GO:0005768 endosome cellular_component organelle 17 255 724 25187 0.023481 0.001211 0.017915
GO:0045202 synapse cellular_component synapse 17 255 723 25187 0.023513 0.001193 0.017915
GO:0001401 mitochondrial sorting and assembly machinery complex cellular_component organelle 2 255 6 25187 0.333333 0.001491 0.019776
GO:0031225 anchored component of membrane cellular_component membrane 7 255 165 25187 0.042424 0.001504 0.019776
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) cellular_component membrane 2 255 6 25187 0.333333 0.001491 0.019776
GO:0030054 cell junction cellular_component cell junction 21 255 1016 25187 0.020669 0.001652 0.020218
GO:0030666 endocytic vesicle membrane cellular_component organelle 6 255 123 25187 0.04878 0.001609 0.020218
GO:0042584 chromaffin granule membrane cellular_component organelle 2 255 7 25187 0.285714 0.002073 0.023744
GO:0045254 pyruvate dehydrogenase complex cellular_component cell part 2 255 7 25187 0.285714 0.002073 0.023744
GO:0044306 neuron projection terminus cellular_component cell part 3 255 26 25187 0.115385 0.002245 0.024901
GO:0030315 T-tubule cellular_component cell part 4 255 55 25187 0.072727 0.002334 0.025113
GO:0043190 ATP-binding cassette (ABC) transporter complex cellular_component membrane 2 255 8 25187 0.25 0.002746 0.027854
GO:1990246 uniplex complex cellular_component organelle 2 255 8 25187 0.25 0.002746 0.027854
GO:0030424 axon cellular_component cell part 12 255 466 25187 0.025751 0.002996 0.028964
GO:0042645 mitochondrial nucleoid enclosed lumen cellular_component membrane- 4 255 59 25187 0.067797 0.003019 0.028964
GO:0030658 transport vesicle membrane cellular_component organelle 5 255 98 25187 0.05102 0.003233 0.030206
GO:0042734 presynaptic membrane cellular_component membrane 5 255 100 25187 0.05 0.003527 0.032102
GO:0008091 spectrin cellular_component organelle 2 255 10 25187 0.2 0.004355 0.037706
GO:0032592 integral component of mitochondrial membrane cellular_component organelle 2 255 10 25187 0.2 0.004355 0.037706
GO:0043005 neuron projection cellular_component cell part 2 12 255 496 25187 0.024194 0.004908 0.041487
GO:0005921 gap junction cellular_component cell junction 3 255 35 25187 0.085714 0.005285 0.042658
GO:0014731 spectrin-associated cytoskeleton cellular_component organelle 2 255 11 25187 0.181818 0.005287 0.042658
GO:0005834 heterotrimeric G-protein complex cellular_component membrane 3 255 36 25187 0.083333 0.005723 0.045144
GO:0043204 perikaryon cellular_component cell part 6 255 160 25187 0.0375 0.005897 0.045509
GO:0009898 cytoplasmic side of plasma membrane cellular_component membrane 4 255 76 25187 0.052632 0.007447 0.05508
GO:0031982 vesicle cellular_component organelle 7 255 220 25187 0.031818 0.007313 0.05508
GO:0005586 collagen type III trimer cellular_component extracellular region 1 255 1 25187 1 0.010124 0.061968
GO:0009295 nucleoid cellular_component part nucleoid 1 255 1 25187 1 0.010124 0.061968
GO:0020003 symbiont-containing vacuole cellular_component organelle 1 255 1 25187 1 0.010124 0.061968
GO:0020005 symbiont-containing vacuole membrane cellular_component organelle 1 255 1 25187 1 0.010124 0.061968
GO:0031305 integral component of mitochondrial inner membrane cellular_component organelle 3 255 44 25187 0.068182 0.010005 0.061968
GO:0033017 sarcoplasmic reticulum membrane cellular_component organelle 3 255 43 25187 0.069767 0.009392 0.061968
GO:0034358 plasma lipoprotein particle cellular_component extracellular region part 1 255 1 25187 1 0.010124 0.061968
GO:0034466 chromaffin granule lumen cellular_component organelle 1 255 1 25187 1 0.010124 0.061968
GO:0099189 postsynaptic spectrin- associated cytoskeleton cellular_component organelle 1 255 1 25187 1 0.010124 0.061968
GO:1990031 pinceau fiber cellular_component cell part 1 255 1 25187 1 0.010124 0.061968
GO:0005614 interstitial matrix cellular_component extracellular region 2 255 16 25187 0.125 0.011158 0.064935
GO:0016471 vacuolar proton- transporting V-type ATPase complex cellular_component part organelle 2 255 16 25187 0.125 0.011158 0.064935
GO:0099738 cell cortex region cellular_component cell part 2 255 16 25187 0.125 0.011158 0.064935
GO:0031226 intrinsic component of plasma membrane cellular_component membrane 3 255 47 25187 0.06383 0.011981 0.068601
GO:0005740 mitochondrial envelope cellular_component organelle 2 255 17 25187 0.117647 0.012562 0.070785
GO:0030672 synaptic vesicle membrane cellular_component organelle 4 255 90 25187 0.044444 0.013298 0.073764
GO:0005750 mitochondrial respiratory chain cellular_component organelle 2 255 20 25187 0.1 0.017204 0.092537
GO:0015629 actin cytoskeleton cellular_component organelle 8 255 321 25187 0.024922 0.017011 0.092537
GO:0005922 connexin complex cellular_component membrane 2 255 22 25187 0.090909 0.020641 0.096417
GO:0005954 calcium- and calmodulin-dependent protein kinase complex cellular_component cell part 1 255 2 25187 0.5 0.020146 0.096417
GO:0008076 voltage-gated potassium channel complex cellular_component membrane 4 255 99 25187 0.040404 0.018269 0.096417
GO:0009353 mitochondrial oxoglutarate dehydrogenase complex cellular_component membrane-enclosed lumen 1 255 2 25187 0.5 0.020146 0.096417
GO:0019008 molybdopterin synthase complex cellular_component cell part 1 255 2 25187 0.5 0.020146 0.096417
GO:0032473 cytoplasmic side of mitochondrial outer membrane cellular_component organelle 1 255 2 25187 0.5 0.020146 0.096417
GO:0060987 lipid tube cellular_component protein-containing complex 1 255 2 25187 0.5 0.020146 0.096417
GO:0097180 serine protease inhibitor complex cellular_component protein-containing complex 1 255 2 25187 0.5 0.020146 0.096417
GO:0098688 parallel fiber to Purkinje cell synapse cellular_component synapse 2 255 22 25187 0.090909 0.020641 0.096417
GO:0099160 postsynaptic intermediate filament cytoskeleton cellular_component organelle 1 255 2 25187 0.5 0.020146 0.096417
GO:0005868 cytoplasmic dynein complex cellular_component organelle 2 255 23 25187 0.086957 0.022458 0.103542
GO:0010008 endosome membrane cellular_component membrane 8 255 340 25187 0.023529 0.023063 0.104967
GO:0031201 SNARE complex cellular_component membrane 3 255 62 25187 0.048387 0.02503 0.112479
GO:0034361 very-low-density lipoprotein particle cellular_component extracellular region part 2 255 25 25187 0.08 0.026281 0.116623
GO:0031410 cytoplasmic vesicle cellular_component organelle 14 255 776 25187 0.018041 0.027302 0.119657
GO:0005945 6-phosphofructokinase complex cellular_component cell part 1 255 3 25187 0.333333 0.030068 0.120195
GO:0016021 integral component of membrane cellular_component membrane 86 255 7102 25187 0.012109 0.030133 0.120195
GO:0020018 ciliary pocket membrane cellular_component organelle 1 255 3 25187 0.333333 0.030068 0.120195
GO:0043296 apical junction complex cellular_component cell junction 2 255 26 25187 0.076923 0.028284 0.120195
GO:0045177 apical part of cell cellular_component cell 4 255 113 25187 0.035398 0.028042 0.120195
GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane cellular_component organelle 1 255 3 25187 0.333333 0.030068 0.120195
GO:0098560 cytoplasmic side of late endosome membrane cellular_component membrane 1 255 3 25187 0.333333 0.030068 0.120195
GO:0099503 secretory vesicle cellular_component organelle 1 255 3 25187 0.333333 0.030068 0.120195
GO:0034774 secretory granule lumen cellular_component organelle 5 255 172 25187 0.02907 0.031036 0.122421
GO:0005753 mitochondrial proton-transporting ATP synthase complex cellular_component organelle 2 255 28 25187 0.071429 0.032467 0.122613
GO:0005783 endoplasmic reticulum cellular_component organelle 27 255 1831 25187 0.014746 0.031832 0.122613
GO:0016459 myosin complex cellular_component organelle 3 255 68 25187 0.044118 0.031747 0.122613
GO:0034704 calcium channel cellular_component membrane 2 255 28 25187 0.071429 0.032467 0.122613
GO:0030425 dendrite cellular_component cell part 11 255 582 25187 0.0189 0.035725 0.132106
GO:0098685 Schaffer collateral - CA1 synapse cellular_component synapse 4 255 122 25187 0.032787 0.035692 0.132106
GO:0005846 nuclear cap binding complex cellular_component cell part 1 255 4 25187 0.25 0.039889 0.134861
GO:0016529 sarcoplasmic reticulum cellular_component organelle 3 255 74 25187 0.040541 0.03931 0.134861
GO:0030027 lamellipodium cellular_component cell part 6 255 245 25187 0.02449 0.039092 0.134861
GO:0030478 actin cap cellular_component organelle 1 255 4 25187 0.25 0.039889 0.134861
GO:0034518 RNA cap binding complex cellular_component protein-containing complex 1 255 4 25187 0.25 0.039889 0.134861
GO:0034686 integrin alphav-beta8 complex cellular_component membrane 1 255 4 25187 0.25 0.039889 0.134861
GO:0042588 zymogen granule cellular_component organelle 1 255 4 25187 0.25 0.039889 0.134861
GO:0060203 clathrin-sculpted glutamate transport vesicle membrane cellular_component organelle 1 255 4 25187 0.25 0.039889 0.134861
GO:0098559 cytoplasmic side of early endosome membrane cellular_component membrane 1 255 4 25187 0.25 0.039889 0.134861
GO:0042613 MHC class II protein complex cellular_component membrane 3 255 76 25187 0.039474 0.042016 0.140714
GO:0045121 membrane raft cellular_component membrane 7 255 317 25187 0.022082 0.043252 0.1435
GO:0031307 integral component of mitochondrial outer membrane cellular_component organelle 2 255 33 25187 0.060606 0.043886 0.144256
GO:0005947 mitochondrial alpha- ketoglutarate dehydrogenase complex cellular_component membrane- enclosed lumen 1 255 5 25187 0.2 0.049611 0.151825
GO:0014704 intercalated disc cellular_component cell junction 3 255 81 25187 0.037037 0.049178 0.151825
GO:0016342 catenin complex cellular_component membrane 2 255 35 25187 0.057143 0.048812 0.151825
GO:0033557 Slx1-Slx4 complex enclosed lumen cellular_component membrane- 1 255 5 25187 0.2 0.049611 0.151825
GO:0070032 synaptobrevin 2-SNAP- 25-syntaxin-1a- complexin I complex cellular_component membrane 1 255 5 25187 0.2 0.049611 0.151825
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane cellular_component organelle 1 255 5 25187 0.2 0.049611 0.151825
GO:0098857 membrane microdomain cellular_component membrane 1 255 5 25187 0.2 0.049611 0.151825
GO:1990726 Lsm1-7-Pat1 complex cellular_component protein-containing complex 1 255 5 25187 0.2 0.049611 0.151825