Additional Table 8.
KEGG pathway analysis of differentially expressed proteins
| Term | Total | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| KEGG | Candidat | Candidat Term | Total | |||||||
| Pathway | KEGG Pathway Term | KEGG Pathway | e Gene | e Gene | Gene | Gene | Rich | |||
| Term ID | KEGG Pathway Term Desc | Level1 | Term Level2 | Num | Num | Num | Num | Ratio | P value | Q value |
| 5012 | Parkinson’s disease | Human Diseases | Neurodegenerative diseases | 20 | 187 | 209 | 15870 | 0.09569 | 5.64E-13 | 1.60E-10 |
| 1100 | Metabolic pathways | Metabolism | Global and overview rn r* k—\ r» | 58 | 187 | 1923 | 15870 | 0.03016 | 4.81E-12 | 6.81E-10 |
| 5016 | Huntington’s disease | Human Diseases | maps Neurodegenerative diseases | 19 | 187 | 283 | 15870 | 0.06714 | 1.03E-09 | 9.72E-08 |
| 190 | Oxidative phosphorylation | Metabolism | Energy metabolism | 15 | 187 | 195 | 15870 | 0.07692 | 1.04E-08 | 7.33E-07 |
| 4714 | Thermogenesis | Organismal Systems | Environmental adaptation | 17 | 187 | 318 | 15870 | 0.05346 | 2.27E-07 | 1.28E-05 |
| 5010 | Alzheimer’s disease | Human Diseases | Neurodegenerative diseases | 15 | 187 | 256 | 15870 | 0.05859 | 3.76E-07 | 1.77E-05 |
| 1110 | Biosynthesis of secondary metabolites | Metabolism | Global and overview | 21 | 187 | 558 | 15870 | 0.03763 | 2.73E-06 | 1.10E-04 |
| 4020 | Calcium signaling pathway | Environmental Information Processing | maps Signal transduction | 12 | 187 | 256 | 15870 | 0.04688 | 5.27E-05 | 0.00186 |
| 4932 | Non-alcoholic fatty liver disease (NAFLD) | Human Diseases | Endocrine and metabolic diseases | 11 | 187 | 250 | 15870 | 0.044 | 1.89E-04 | 0.00594 |
| 350 | Tyrosine metabolism | Metabolism | Amino acid metabolism | 5 | 187 | 48 | 15870 | 0.10417 | 2.44E-04 | 0.00629 |
| 4922 | Glucagon signaling pathway | Organismal Systems | Endocrine system | 8 | 187 | 138 | 15870 | 0.05797 | 2.30E-04 | 0.00629 |
| 4723 | Retrograde endocannabinoid signaling | Organismal Systems | Nervous system | 9 | 187 | 180 | 15870 | 0.05 | 2.86E-04 | 0.00675 |
| 1200 | Carbon metabolism | Metabolism | Global and overview | 9 | 187 | 189 | 15870 | 0.04762 | 4.10E-04 | 0.00892 |
| 950 | Isoquinoline alkaloid biosynthesis | Metabolism | maps Biosynthesis of other secondary metabolites | 3 | 187 | 14 | 15870 | 0.21429 | 5.33E-04 | 0.01005 |
| 4217 | Necroptosis | Cellular Processes | Cell growth and /-J /~\ r* -I- L-\ death | 10 | 187 | 236 | 15870 | 0.04237 | 4.97E-04 | 0.01005 |
| 4979 | Cholesterol metabolism | Organismal Systems | Digestive system | 5 | 187 | 60 | 15870 | 0.08333 | 6.96E-04 | 0.01231 |
| 1120 | Microbial metabolism in diverse environments | Metabolism | Global and overview maps | 10 | 187 | 250 | 15870 | 0.04 | 7.77E-04 | 0.01267 |
| 4971 | Gastric acid secretion | Organismal Systems | Digestive system | 6 | 187 | 93 | 15870 | 0.06452 | 8.06E-04 | 0.01267 |
| 4260 | Cardiac muscle contraction | Organismal Systems | Circulatory system | 6 | 187 | 97 | 15870 | 0.06186 | 0.001 | 0.01497 |
| 4978 | Mineral absorption | Organismal Systems | Digestive system | 5 | 187 | 66 | 15870 | 0.07576 | 0.00108 | 0.01522 |
| 4728 | Dopaminergic synapse | Organismal Systems | Nervous system | 8 | 187 | 177 | 15870 | 0.0452 | 0.0012 | 0.01616 |
| 4725 | Cholinergic synapse | Organismal Systems | Nervous system | 7 | 187 | 145 | 15870 | 0.04828 | 0.00166 | 0.02136 |
| 1130 | Biosynthesis of antibiotics | Metabolism | Global and overview rn r* k—\ r» | 11 | 187 | 327 | 15870 | 0.03364 | 0.00175 | 0.02154 |
| 4730 | Long-term depression | Organismal Systems | maps Nervous system | 5 | 187 | 75 | 15870 | 0.06667 | 0.00191 | 0.0225 |
| 360 | Phenylalanine metabolism | Metabolism | Amino acid metabolism | 3 | 187 | 22 | 15870 | 0.13636 | 0.0021 | 0.02284 |
| 4218 | Cellular senescence | Cellular Processes | Cell growth and | 10 | 187 | 287 | 15870 | 0.03484 | 0.00218 | 0.02284 |
| 4921 | Oxytocin signaling pathway | Organismal Systems | death Endocrine system | 8 | 187 | 194 | 15870 | 0.04124 | 0.00214 | 0.02284 |
| 5031 | Amphetamine addiction | Human Diseases | Substance dependence | 5 | 187 | 86 | 15870 | 0.05814 | 0.00347 | 0.03401 |
| 5216 | Thyroid cancer | Human Diseases | Cancers: Specific types | 4 | 187 | 53 | 15870 | 0.07547 | 0.00348 | 0.03401 |
| 4720 | Long-term potentiation | Organismal Systems | Nervous system | 5 | 187 | 88 | 15870 | 0.05682 | 0.00383 | 0.03593 |
| 4916 | Melanogenesis | Organismal Systems | Endocrine system | 6 | 187 | 127 | 15870 | 0.04724 | 0.00394 | 0.03593 |
| 4022 | cGMP-PKG signaling pathway | Environmental Information Processing | Signal transduction | 8 | 187 | 228 | 15870 | 0.03509 | 0.00569 | 0.05033 |
| 4514 | Cell adhesion molecules (CAMs) | Environmental Information Processing | Signaling molecules and interaction | 9 | 187 | 279 | 15870 | 0.03226 | 0.00591 | 0.05068 |
| 790 | Folate biosynthesis | Metabolism | Metabolism of cofactors and vitamins | 3 | 187 | 33 | 15870 | 0.09091 | 0.00677 | 0.05544 |
| 3320 | PPAR signaling pathway | Organismal Systems | Endocrine system | 5 | 187 | 101 | 15870 | 0.0495 | 0.00686 | 0.05544 |
| 4216 | Ferroptosis | Cellular Processes | Cell growth and /-J /~\ r* -I- L-\ death | 4 | 187 | 65 | 15870 | 0.06154 | 0.00723 | 0.0568 |
| 4911 | Insulin secretion | Organismal Systems | Endocrine system | 5 | 187 | 104 | 15870 | 0.04808 | 0.00774 | 0.0592 |
| 4621 | NOD-like receptor signaling pathway | Organismal Systems | Immune system | 8 | 187 | 247 | 15870 | 0.03239 | 0.00904 | 0.06734 |
| 4972 | Pancreatic secretion | Organismal Systems | Digestive system | 5 | 187 | 111 | 15870 | 0.04505 | 0.0101 | 0.07331 |
| 4745 | Phototransduction - fly | Organismal Systems | Sensory system | 3 | 187 | 39 | 15870 | 0.07692 | 0.01078 | 0.07625 |
| 30 | Pentose phosphate pathway | Metabolism | Carbohydrate metabolism | 3 | 187 | 41 | 15870 | 0.07317 | 0.01236 | 0.08032 |
| 52 | Galactose metabolism | Metabolism | Carbohydrate metabolism | 3 | 187 | 41 | 15870 | 0.07317 | 0.01236 | 0.08032 |
| 4212 | Longevity regulating pathway - worm | Organismal Systems | Aging | 5 | 187 | 117 | 15870 | 0.04274 | 0.01249 | 0.08032 |
| 5034 | Alcoholism | Human Diseases | Substance dependence | 7 | 187 | 208 | 15870 | 0.03365 | 0.01174 | 0.08032 |
| 4912 | GnRH signaling pathway | Organismal Systems | Endocrine system | 5 | 187 | 118 | 15870 | 0.04237 | 0.01292 | 0.08125 |
| 4713 | Circadian entrainment | Organismal Systems | Environmental adaptation | 5 | 187 | 120 | 15870 | 0.04167 | 0.01381 | 0.08497 |
| 480 | Glutathione metabolism | Metabolism | Metabolism of other amino acids | 4 | 187 | 79 | 15870 | 0.05063 | 0.01413 | 0.08507 |
| 5230 | Central carbon metabolism in cancer | Human Diseases | Cancers: Overview | 4 | 187 | 81 | 15870 | 0.04938 | 0.01536 | 0.09059 |
| 4360 | Axon guidance | Organismal Systems | Development | 7 187 | 223 | 15870 | 0.03139 | 0.01665 | 0.09474 | |
| 4925 | Aldosterone synthesis and secretion | Organismal Systems | Endocrine system | 5 | 187 | 126 | 15870 | 0.03968 | 0.01674 | 0.09474 |
| 51 | Fructose and mannose metabolism | Metabolism | Carbohydrate metabolism | 3 | 187 | 47 | 15870 | 0.06383 | 0.01786 | 0.09536 |
| 4371 | Apelin signaling pathway | Environmental Information Processing | Signal transduction | 6 | 187 | 175 | 15870 | 0.03429 | 0.0176 | 0.09536 |
| 4721 | Synaptic vesicle cycle | Organismal Systems | Nervous system | 4 | 187 | 84 | 15870 | 0.04762 | 0.01734 | 0.09536 |
| 4261 | Adrenergic signaling in cardiomyocytes | Organismal Systems | Circulatory system | 6 | 187 | 185 | 15870 | 0.03243 | 0.02245 | 0.11763 |
| 250 | Alanine, aspartate and glutamate metabolism | Metabolism | Amino acid metabolism | 3 | 187 | 52 | 15870 | 0.05769 | 0.02333 | 0.12003 |
| 10 | Glycolysis / Gluconeogenesis | Metabolism | Carbohydrate metabolism | 4 | 187 | 94 | 15870 | 0.04255 | 0.02506 | 0.12664 |
| 4640 | Hematopoietic cell lineage | Organismal Systems | Immune system | 6 | 187 | 194 | 15870 | 0.03093 | 0.02751 | 0.1366 |
| 20 | Citrate cycle (TCA cycle) | Metabolism | Carbohydrate metabolism | 3 | 187 | 58 | 15870 | 0.05172 | 0.03095 | 0.14129 |
| 71 | Fatty acid degradation | Metabolism | Lipid metabolism | 3 | 187 | 57 | 15870 | 0.05263 | 0.0296 | 0.14129 |
| 4066 | HIF-1 signaling pathway | Environmental Information Processing | Signal transduction | 5 | 187 | 148 | 15870 | 0.03378 | 0.03089 | 0.14129 |
| 4726 | Serotonergic synapse | Organismal Systems | Nervous system | 5 | 187 | 147 | 15870 | 0.03401 | 0.03012 | 0.14129 |
| 5214 | Glioma | Human Diseases | Cancers: Specific types | 4 | 187 | 100 | 15870 | 0.04 | 0.03054 | 0.14129 |
| 1230 | Biosynthesis of amino acids | Metabolism | Global and overview rn r* k—\ r» | 4 | 187 | 104 | 15870 | 0.03846 | 0.03455 | 0.15501 |
| 4974 | Protein digestion and absorption | Organismal Systems | maps Digestive system | 4 | 187 | 105 | 15870 | 0.0381 | 0.0356 | 0.15501 |
| 5030 | Cocaine addiction | Human Diseases | Substance dependence | 3 | 187 | 61 | 15870 | 0.04918 | 0.0352 | 0.15501 |
| 330 | Arginine and proline metabolism | Metabolism | Amino acid metabolism | 3 | 187 | 63 | 15870 | 0.04762 | 0.03819 | 0.15716 |
| 340 | Histidine metabolism | Metabolism | Amino acid metabolism | 2 | 187 | 27 | 15870 | 0.07407 | 0.03997 | 0.15716 |
| 520 | Amino sugar and nucleotide sugar metabolism | Metabolism | Carbohydrate metabolism | 3 | 187 | 64 | 15870 | 0.04688 | 0.03973 | 0.15716 |
| 4012 | ErbB signaling pathway | Environmental Information Processing | Signal transduction | 4 | 187 | 109 | 15870 | 0.0367 | 0.03999 | 0.15716 |
| 4727 | GABAergic synapse | Organismal Systems | Nervous system | 4 | 187 | 108 | 15870 | 0.03704 | 0.03886 | 0.15716 |
| 5110 | Vibrio cholerae infection | Human Diseases | Infectious diseases: Bacterial | 3 | 187 | 62 | 15870 | 0.04839 | 0.03668 | 0.15716 |
| 5166 | HTLV-I infection | Human Diseases | Infectious diseases: Viral | 10 | 187 | 447 | 15870 | 0.02237 | 0.03928 | 0.15716 |
| 4722 | Neurotrophin signaling pathway | Organismal Systems | Nervous system | 5 | 187 | 160 | 15870 | 0.03125 | 0.04105 | 0.15728 |
| 4970 | Salivary secretion | Organismal Systems | Digestive system | 4 | 187 | 110 | 15870 | 0.03636 | 0.04113 | 0.15728 |
| 4015 | Rap1 signaling pathway | Environmental Information Processing | Signal transduction | 7 | 187 | 273 | 15870 | 0.02564 | 0.04316 | 0.16287 |
| 1212 | Fatty acid metabolism | Metabolism | Global and overview rn r* \ r. | 3 | 187 | 69 | 15870 | 0.04348 | 0.0479 | 0.17797 |
| 4614 | Renin-angiotensin system | Organismal Systems | maps Endocrine system | 2 | 187 | 30 | 15870 | 0.06667 | 0.04842 | 0.17797 |
KEGG: Kyoto Encyclopedia of Genes and Genomes.