Additional Table 13.
GO molecular function analysis of filtered mRNAs
| ONTOLOGY | GOID | Description | GeneRatio | BgRatio | pvalue | p.adjust | geneID | Count |
|---|---|---|---|---|---|---|---|---|
| MF | GO:0005125 | cytokine activity | 23/646 | 218/17258 | 7.74E-06 | 0.00276242 | CXCL11/TNFSF10/TNFSF13/IL1A/IL1B/INHA/EBI3/EDN1/NRG1/AREG/IL6/IL7/LIF/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/CCL7/TNFRSF11B/CSF3/CCL20/IL12A | 23 |
| MF | GO:0048018 | receptor ligand activity | 37/646 | 454/17258 | 8.15E-06 | 0.00276242 | CXCL11/TNFSF10/TNFSF13/IL1A/IL1B/INHA/EBI3/EDN1/ADA2/ERFE/EREG/PTHLH/SFRP2/NRG1/NRG2/NRG4/AREG/FNDC5/AMH/IL6/IL7/LIF/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/SPX/UCN/GHRL/CCL7/TNFRSF11B/PSPN/CSF3/CCL20/EPHA7/IL12A | 37 |
| MF | GO:0030545 | receptor regulator activity | 38/646 | 483/17258 | 1.38E-05 | 0.00276242 | CXCL11/TNFSF10/TNFSF13/IL1A/IL1B/INHA/EBI3/EDN1/ADA2/ERFE/EREG/PTHLH/SFRP2/NRG1/NRG2/NRG4/AREG/FNDC5/AMH/IL6/IL7/LIF/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/WFIKKN1/SPX/UCN/GHRL/CCL7/TNFRSF11B/PSPN/CSF3/CCL20/EPHA7/IL12A | 38 |
| MF | GO:0045236 | CXCR chemokine receptor binding | 6/646 | 16/17258 | 1.56E-05 | 0.00276242 | CXCL11/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5 | 6 |
| MF | GO:0008009 | chemokine activity | 8/646 | 46/17258 | 0.00027339 | 0.02748107 | CXCL11/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/CCL7/CCL20 | 8 |
| MF | GO:0022836 | gated channel activity | 26/646 | 332/17258 | 0.00033158 | 0.02748107 | CHRNE/CHRNA10/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/ANO1/ASIC3/JPH2/GRID2/GRIK5/GABRA2/GABRA5/SCN1A/SCN3B/SCN3A/P2RX6/GRIN2C/GRIN2D/GRIN3A/PIEZO2/CLIC6/CLIC2/CATSPER1/GPR89B | 26 |
| MF | GO:0005231 | excitatory extracellular ligand-gatedion channel activity | 8/646 | 48/17258 | 0.0003702 | 0.02748107 | CHRNE/CHRNA10/GRID2/GRIK5/P2RX6/GRIN2C/GRIN2D/GRIN3A | 8 |
| MF | GO:0005230 | extracellular ligand-gated ionchannel activity | 10/646 | 75/17258 | 0.00046517 | 0.02748107 | CHRNE/CHRNA10/GRID2/GRIK5/GABRA2/GABRA5/P2RX6/GRIN2C/GRIN2D/GRIN3A | 10 |
| MF | GO:0043178 | alcohol binding | 10/646 | 75/17258 | 0.00046517 | 0.02748107 | TRPC4/RBP4/RBP1/APOE/NR1H3/SYP/CETP/LRAT/PROM2/OSBP2 | 10 |
| MF | GO:0022824 | transmitter-gated ion channelactivity | 8/646 | 50/17258 | 0.00049322 | 0.02748107 | CHRNE/CHRNA10/GRID2/GRIK5/GABRA2/GRIN2C/GRIN2D/GRIN3A | 8 |
| MF | GO:0022835 | transmitter-gated channel activity | 8/646 | 50/17258 | 0.00049322 | 0.02748107 | CHRNE/CHRNA10/GRID2/GRIK5/GABRA2/GRIN2C/GRIN2D/GRIN3A | 8 |
| MF | GO:0005520 | insulin-like growth factor binding | 6/646 | 28/17258 | 0.00050026 | 0.02748107 | HTRA4/WISP1/IGFBP5/KAZALD1/ITGB4/ITGA6 | 6 |
| MF | GO:0004970 | ionotropic glutamate receptoractivity | 5/646 | 19/17258 | 0.00054341 | 0.02748107 | GRID2/GRIK5/GRIN2C/GRIN2D/GRIN3A | 5 |
| MF | GO:0005234 | extracellularly glutamate-gated ionchannel activity | 5/646 | 19/17258 | 0.00054341 | 0.02748107 | GRID2/GRIK5/GRIN2C/GRIN2D/GRIN3A | 5 |
| MF | GO:0005201 | extracellular matrix structuralconstituent | 10/646 | 78/17258 | 0.00063874 | 0.03014845 | COL14A1/HAPLN3/COL19A1/TECTA/ENAM/ELN/CHI3L1/COL5A3/COL4A3/MATN3 | 10 |
| MF | GO:0005216 | ion channel activity | 30/646 | 425/17258 | 0.00069167 | 0.03025376 | CHRNE/CHRNA10/TRPC4/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/LRRC8E/SLC40A1/ANO1/ASIC3/JPH2/GRID2/GRIK5/ABCC9/GABRA2/GABRA5/SCN1A/SCN3B/SCN3A/P2RX6/GRIN2C/GRIN2D/GRIN3A/PIEZO2/CLIC6/CLIC2/CATSPER1/GPR89B | 30 |
| MF | GO:0015267 | channel activity | 32/646 | 466/17258 | 0.00074207 | 0.03025376 | CHRNE/CHRNA10/TRPC4/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/LRRC8E/SLC40A1/ANO1/ASIC3/JPH2/GRID2/GRIK5/ABCC9/GABRA2/GABRA5/SCN1A/SCN3B/SCN3A/BCL2A1/P2RX6/GJB7/GRIN2C/GRIN2D/GRIN3A/PIEZO2/CLIC6/CLIC2/CATSPER1/GPR89B | 32 |
| MF | GO:0022803 | passive transmembrane transporteractivity | 32/646 | 467/17258 | 0.00076916 | 0.03025376 | CHRNE/CHRNA10/TRPC4/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/LRRC8E/SLC40A1/ANO1/ASIC3/JPH2/GRID2/GRIK5/ABCC9/GABRA2/GABRA5/SCN1A/SCN3B/SCN3A/BCL2A1/P2RX6/GJB7/GRIN2C/GRIN2D/GRIN3A/PIEZO2/CLIC6/CLIC2/CATSPER1/GPR89B | 32 |
| MF | GO:0022838 | substrate-specific channel activity | 30/646 | 435/17258 | 0.00100299 | 0.03737468 | CHRNE/CHRNA10/TRPC4/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/LRRC8E/SLC40A1/ANO1/ASIC3/JPH2/GRID2/GRIK5/ABCC9/GABRA2/GABRA5/SCN1A/SCN3B/SCN3A/P2RX6/GRIN2C/GRIN2D/GRIN3A/PIEZO2/CLIC6/CLIC2/CATSPER1/GPR89B | 30 |
| MF | GO:0015245 | fatty acid transporter activity | 4/646 | 13/17258 | 0.00106137 | 0.03757264 | MFSD2A/SLCO2A1/FABP3/SLC27A5 | 4 |
| MF | GO:0008083 | growth factor activity | 15/646 | 162/17258 | 0.00113973 | 0.03842505 | INHA/ADA2/EREG/NRG1/NRG2/NRG4/AREG/AMH/IL6/IL7/LIF/CXCL1/PSPN/CSF3/IL12A | 15 |
| MF | GO:0042379 | chemokine receptor binding | 8/646 | 58/17258 | 0.00135494 | 0.04360441 | CXCL11/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/CCL7/CCL20 | 8 |
| MF | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | 4/646 | 14/17258 | 0.0014422 | 0.04439455 | B3GALT2/B3GALT1/B3GALT5/B3GNT4 | 4 |
| MF | GO:0005261 | cation channel activity | 23/646 | 314/17258 | 0.00174445 | 0.05146139 | CHRNE/CHRNA10/TRPC4/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/SLC40A1/ANO1/ASIC3/JPH2/GRIK5/ABCC9/SCN1A/SCN3B/SCN3A/P2RX6/GRIN2C/GRIN2D/GRIN3A/PIEZO2/CATSPER1 | 23 |
| MF | GO:0005319 | lipid transporter activity | 13/646 | 141/17258 | 0.0024669 | 0.06573686 | SLC10A4/RBP4/TMEM30B/APOE/MFSD2A/SLCO2A1/ABCB4/FABP3/SPNS2/CETP/PITPNM3/SLC27A5/ATP10B | 13 |
| MF | GO:0048531 | beta-1,3-galactosyltransferaseactivity | 4/646 | 16/17258 | 0.00247041 | 0.06573686 | B3GALT2/B3GALT1/B3GALT5/B3GNT4 | 4 |
| MF | GO:0005126 | cytokine receptor binding | 20/646 | 266/17258 | 0.00250691 | 0.06573686 | CXCL11/TNFSF10/TNFSF13/IL1A/IL1B/INHA/EBI3/AMH/IL6/IL7/LIF/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/CCL7/CSF3/CCL20/IL12A | 20 |
| MF | GO:0008066 | glutamate receptor activity | 5/646 | 27/17258 | 0.00294555 | 0.07448045 | GRID2/GRIK5/GRIN2C/GRIN2D/GRIN3A | 5 |
| MF | GO:0019838 | growth factor binding | 12/646 | 130/17258 | 0.00352661 | 0.08609797 | HTRA4/WISP1/FLT4/A2M/ACVR1C/WFIKKN1/S100A13/IGFBP5/KAZALD1/HAP1/ITGB4/ITGA6 | 12 |
| MF | GO:0004222 | metalloendopeptidase activity | 11/646 | 115/17258 | 0.00389625 | 0.09195151 | PAPLN/MMP3/MMP8/TMPRSS6/KEL/ADAMTS14/ADAMTS19/MMP10/TLL2/ADAM28/ADAM33 | 11 |
| MF | GO:0001664 | G-protein coupled receptor binding | 19/646 | 260/17258 | 0.00432576 | 0.09879484 | C3/CXCL11/RAMP1/EDN1/ADA2/WNT16/CXCL6/CXCL8/CXCL1/CXCL3/CXCL5/UCN/NECAB2/GHRL/GNAZ/CCL7/CCL20/GPRC5B/ITGB4 | 19 |
| MF | GO:0015485 | cholesterol binding | 6/646 | 43/17258 | 0.00503575 | 0.11141589 | APOE/NR1H3/SYP/CETP/PROM2/OSBP2 | 6 |
| MF | GO:0015276 | ligand-gated ion channel activity | 12/646 | 139/17258 | 0.00602901 | 0.12554528 | CHRNE/CHRNA10/ASIC3/JPH2/GRID2/GRIK5/GABRA2/GABRA5/P2RX6/GRIN2C/GRIN2D/GRIN3A | 12 |
| MF | GO:0022834 | ligand-gated channel activity | 12/646 | 139/17258 | 0.00602901 | 0.12554528 | CHRNE/CHRNA10/ASIC3/JPH2/GRID2/GRIK5/GABRA2/GABRA5/P2RX6/GRIN2C/GRIN2D/GRIN3A | 12 |
| MF | GO:0061135 | endopeptidase regulator activity | 14/646 | 177/17258 | 0.00682657 | 0.13526148 | C3/SERPINE3/SERPINF1/PAPLN/SERPINB12/BIRC3/SFRP2/NLRC4/A2M/WFIKKN1/COL4A3/SPINT2/SPINT1/HMSD | 14 |
| MF | GO:0086080 | protein binding involved inheterotypic cell-cell adhesion | 3/646 | 11/17258 | 0.0068777 | 0.13526148 | DSC2/CXADR/NFASC | 3 |
| MF | GO:0005496 | steroid binding | 9/646 | 92/17258 | 0.00748345 | 0.13953101 | PAQR5/HSD11B2/ESR1/APOE/NR1H3/SYP/CETP/PROM2/OSBP2 | 9 |
| MF | GO:0005244 | voltage-gated ion channel activity | 15/646 | 198/17258 | 0.00768603 | 0.13953101 | KCND1/KCNG2/KCNE3/KCNQ5/ANO1/SCN1A/SCN3B/SCN3A/GRIN2C/GRIN2D/GRIN3A/CLIC6/CLIC2/CATSPER1/GPR89B | 15 |
| MF | GO:0022832 | voltage-gated channel activity | 15/646 | 198/17258 | 0.00768603 | 0.13953101 | KCND1/KCNG2/KCNE3/KCNQ5/ANO1/SCN1A/SCN3B/SCN3A/GRIN2C/GRIN2D/GRIN3A/CLIC6/CLIC2/CATSPER1/GPR89B | 15 |
| MF | GO:0004867 | serine-type endopeptidase inhibitoractivity | 9/646 | 93/17258 | 0.00801867 | 0.14030831 | SERPINE3/SERPINF1/PAPLN/SERPINB12/A2M/WFIKKN1/SPINT2/SPINT1/HMSD | 9 |
| MF | GO:0004497 | monooxygenase activity | 9/646 | 94/17258 | 0.00858253 | 0.14030831 | CYP4F3/CYP2W1/CYP4X1/AGMO/FMO2/FMO3/CYP11A1/CYP1A1/CYP27A1 | 9 |
| MF | GO:0032934 | sterol binding | 6/646 | 48/17258 | 0.00866409 | 0.14030831 | APOE/NR1H3/SYP/CETP/PROM2/OSBP2 | 6 |
| MF | GO:0005178 | integrin binding | 10/646 | 111/17258 | 0.00874837 | 0.14030831 | ICAM5/WISP1/SFRP2/NRG1/MADCAM1/CXADR/COL4A3/VWF/LCP1/ITGA6 | 10 |
| MF | GO:0005542 | folic acid binding | 3/646 | 12/17258 | 0.0089179 | 0.14030831 | FTCD/GNMT/FTCDNL1 | 3 |
| MF | GO:0031994 | insulin-like growth factor I binding | 3/646 | 12/17258 | 0.0089179 | 0.14030831 | IGFBP5/ITGB4/ITGA6 | 3 |
| MF | GO:0099094 | ligand-gated cation channel activity | 8/646 | 80/17258 | 0.01002526 | 0.15430186 | CHRNE/CHRNA10/ASIC3/JPH2/GRIK5/GRIN2C/GRIN2D/GRIN3A | 8 |
| MF | GO:0008237 | metallopeptidase activity | 14/646 | 186/17258 | 0.01035614 | 0.15600316 | PAPLN/MMP3/MMP8/TMPRSS6/KEL/ADAMTS14/ADAMTS19/MMP10/TLL2/ADAM28/ADAM33/CPB2/CPA5/CPA4 | 14 |
| MF | GO:0043225 | ATPase-coupled aniontransmembrane transporter activity | 3/646 | 13/17258 | 0.01127486 | 0.16630417 | ABCC2/ABCC6/ABCC9 | 3 |
| MF | GO:0004866 | endopeptidase inhibitor activity | 13/646 | 171/17258 | 0.0122209 | 0.17657951 | C3/SERPINE3/SERPINF1/PAPLN/SERPINB12/BIRC3/NLRC4/A2M/WFIKKN1/COL4A3/SPINT2/SPINT1/HMSD | 13 |
| MF | GO:0098631 | cell adhesion mediator activity | 5/646 | 38/17258 | 0.01307493 | 0.18514099 | DSC2/MADCAM1/CXADR/EPCAM/NFASC | 5 |
| MF | GO:0019841 | retinol binding | 3/646 | 14/17258 | 0.01395649 | 0.19374899 | RBP4/RBP1/LRAT | 3 |
| MF | GO:0005507 | copper ion binding | 6/646 | 55/17258 | 0.01644908 | 0.22396053 | SNAI3/IL1A/AOC2/SCO2/SOD3/S100A13 | 6 |
| MF | GO:0005548 | phospholipid transporter activity | 6/646 | 56/17258 | 0.01785861 | 0.23656451 | TMEM30B/MFSD2A/ABCB4/CETP/PITPNM3/ATP10B | 6 |
| MF | GO:0030414 | peptidase inhibitor activity | 13/646 | 180/17258 | 0.01804306 | 0.23656451 | C3/SERPINE3/SERPINF1/PAPLN/SERPINB12/BIRC3/NLRC4/A2M/WFIKKN1/COL4A3/SPINT2/SPINT1/HMSD | 13 |
| MF | GO:0046873 | metal ion transmembranetransporter activity | 26/646 | 449/17258 | 0.01887147 | 0.24292727 | SLC10A4/SLC11A1/CHRNA10/TRPC4/TRPV4/KCND1/KCNG2/KCNE3/KCNQ5/SLC40A1/ASIC3/JPH2/GRIK5/SLC5A2/SLC1A2/ABCC9/SLC34A3/SCN1A/SCN3B/SCN3A/GRIN2C/GRIN2D/GRIN3A/ATP2C2/CLDN16/CATSPER1 | 26 |
| MF | GO:0048038 | quinone binding | 3/646 | 16/17258 | 0.0203141 | 0.25682829 | VKORC1/AOC2/NDUFS7 | 3 |
| MF | GO:0043492 | ATPase activity, coupled tomovement of substances | 10/646 | 129/17258 | 0.02311831 | 0.28715375 | ATP6V1C2/ABCB6/ABCB4/ABCC2/ABCC6/ABCC9/ATP6V0C/ATP6AP1L/ATP10B/ATP2C2 | 10 |
| MF | GO:0035250 | UDP-galactosyltransferase activity | 4/646 | 30/17258 | 0.02462161 | 0.30016121 | B3GALT2/B3GALT1/B3GALT5/B3GNT4 | 4 |
| MF | GO:0042625 | ATPase coupled ion transmembranetransporter activity | 7/646 | 77/17258 | 0.02501343 | 0.30016121 | ATP6V1C2/ABCC2/ABCC6/ABCC9/ATP6V0C/ATP6AP1L/ATP2C2 | 7 |
| MF | GO:0005272 | sodium channel activity | 5/646 | 45/17258 | 0.02573771 | 0.30370495 | ASIC3/GRIK5/SCN1A/SCN3B/SCN3A | 5 |
| MF | GO:0022853 | active ion transmembranetransporter activity | 10/646 | 132/17258 | 0.02659957 | 0.30856562 | SLC10A4/ATP6V1C2/SLC1A2/ABCC2/ABCC6/ABCC9/SLC34A3/ATP6V0C/ATP6AP1L/ATP2C2 | 10 |
| MF | GO:0042626 | ATPase activity, coupled totransmembrane movement ofsubstances | 9/646 | 114/17258 | 0.02730206 | 0.30856562 | ATP6V1C2/ABCB6/ABCB4/ABCC2/ABCC6/ABCC9/ATP6V0C/ATP6AP1L/ATP2C2 | 9 |
| MF | GO:0098632 | cell-cell adhesion mediator activity | 4/646 | 31/17258 | 0.02745711 | 0.30856562 | DSC2/CXADR/EPCAM/NFASC | 4 |
| MF | GO:0016820 | hydrolase activity, acting on acidanhydrides, catalyzingtransmembrane movement ofsubstances | 9/646 | 116/17258 | 0.03010289 | 0.33136558 | ATP6V1C2/ABCB6/ABCB4/ABCC2/ABCC6/ABCC9/ATP6V0C/ATP6AP1L/ATP2C2 | 9 |
| MF | GO:0005544 | calcium-dependent phospholipidbinding | 5/646 | 47/17258 | 0.03042198 | 0.33136558 | RPH3AL/C2CD4D/SYT17/SYTL3/ANXA8L1 | 5 |
| MF | GO:0030594 | neurotransmitter receptor activity | 8/646 | 99/17258 | 0.03218147 | 0.34196627 | CHRNE/CHRNA10/GRID2/GRIK5/GABRA2/GRIN2C/GRIN2D/GRIN3A | 8 |
| MF | GO:0016289 | CoA hydrolase activity | 3/646 | 19/17258 | 0.03236122 | 0.34196627 | NUDT7/THEM5/ACOT1 | 3 |
| MF | GO:0061134 | peptidase regulator activity | 14/646 | 216/17258 | 0.03297354 | 0.34331273 | C3/SERPINE3/SERPINF1/PAPLN/SERPINB12/BIRC3/SFRP2/NLRC4/A2M/WFIKKN1/COL4A3/SPINT2/SPINT1/HMSD | 14 |
| MF | GO:0008378 | galactosyltransferase activity | 4/646 | 34/17258 | 0.03709021 | 0.36985726 | B3GALT2/B3GALT1/B3GALT5/B3GNT4 | 4 |
| MF | GO:0008395 | steroid hydroxylase activity | 4/646 | 34/17258 | 0.03709021 | 0.36985726 | CYP2W1/CYP11A1/CYP1A1/CYP27A1 | 4 |
| MF | GO:0016709 | oxidoreductase activity, acting onpaired donors, with incorporation orreduction of molecular oxygen,NAD(P)H as one donor, andincorporation of one atom of oxygen | 4/646 | 34/17258 | 0.03709021 | 0.36985726 | CYP4F3/FMO2/FMO3/CYP1A1 | 4 |
| MF | GO:0005179 | hormone activity | 9/646 | 121/17258 | 0.03796825 | 0.37335449 | INHA/EDN1/ERFE/PTHLH/FNDC5/AMH/SPX/UCN/GHRL | 9 |
| MF | GO:0015399 | primary active transmembranetransporter activity | 9/646 | 123/17258 | 0.04147331 | 0.38661999 | ATP6V1C2/ABCB6/ABCB4/ABCC2/ABCC6/ABCC9/ATP6V0C/ATP6AP1L/ATP2C2 | 9 |
| MF | GO:0015405 | P-P-bond-hydrolysis-driventransmembrane transporter activity | 9/646 | 123/17258 | 0.04147331 | 0.38661999 | ATP6V1C2/ABCB6/ABCB4/ABCC2/ABCC6/ABCC9/ATP6V0C/ATP6AP1L/ATP2C2 | 9 |
| MF | GO:0001614 | purinergic nucleotide receptoractivity | 3/646 | 21/17258 | 0.04204765 | 0.38661999 | P2RY6/P2RY2/P2RX6 | 3 |
| MF | GO:0016502 | nucleotide receptor activity | 3/646 | 21/17258 | 0.04204765 | 0.38661999 | P2RY6/P2RY2/P2RX6 | 3 |
| MF | GO:0046961 | proton-transporting ATPase activity,rotational mechanism | 3/646 | 21/17258 | 0.04204765 | 0.38661999 | ATP6V1C2/ATP6V0C/ATP6AP1L | 3 |