Table 1.
Summary of stem cell-based transplantation in the animal model for retinal disease therapy from 2004 to 2022
| Animal | Strain | Transplanted cells | Reference |
|---|---|---|---|
| Mouse | Rho –/– | RPCs | Klassen et al., 2004 |
| C57BL/6 | BMSCs | Li et al., 2007 | |
| ELOVL4 | hESC-RPE cells | Lu, 2009 | |
| Crx –/– | hESC-PR retinal cells | Lamba et al., 2009 | |
| Rpe65rd12/Rpe65rd12 | hESC-RPE cells | Wang, 2010 | |
| Crx –/– | hESC/hiPSC-PR precursors | Lamba et al., 2010 | |
| SCID | miPSC-PR precursors | Tucker, 2011 | |
| NOD-SCID | hCD34+ cells | Park et al., 2012 | |
| C57BL/6Jx129/SvJ | hES-RPCs | Hambright et al., 2012 | |
| Lrat –/– | hiPSC-RPE cells | Maeda, 2013 | |
| RPE65 –/– | hiPSC-RPE cells | Maeda, 2013 | |
| C57BL/6, Gnat1–/–, Prph2rd2/rd2, Nrlp.GFP+/+, Rho–/– | mESC-PR precursors | Gonzalez-Cordero et al., 2013 | |
| rd1 | mESC/miPSC-retina | Assawachanaont et al., 2014 | |
| rd1 | hiPSC-RPE cells | Sun et al., 2015 | |
| rd1 | human CD34+ cells | Moisseiev, 2016 | |
| rd1 | miPSC-retina | Mandai et al., 2017 | |
| Nr1–/–, Prph2rd2/rd2, RPE65R91W/R91W | mESC-retina | Waldron et al., 2018 | |
| NIH III | hESC-RPE cells | da Cruz et al., 2018 | |
| rd1 | hiPSC-RPE cells | Zhu et al., 2020 | |
| NaI03 | hMSCs | Pan, 2020 | |
| NOD-SCID rd1/RCS | hiPSC-RPE/hiPSC-PR precursors | Surendran, 2021 | |
| Rat | RCS | hESC-RPE cells | Lund, 2006 |
| RCS | hiPSC-RPE cells | Carr, 2009 | |
| RCS | hESC-RPE cells | Lu, 2009 | |
| rMSCs | Guan et al., 2013 | ||
| Nude | hESC-RPE cells | Diniz, 2013 | |
| RCS | hRPCs | Luo et al., 2014 | |
| RCS | rMSCs | Jian et al., 2015 | |
| RCS | hUTCs | Cao et al., 2016 | |
| RCS | hESC/hiPSC-RPE cells | Riera et al., 2016 | |
| RCS | hRPCs ± hMSCs | Qu, 2016 | |
| RCS | hESC-RPE cells 3D | Wu, 2016 | |
| RCS | CPCB-RPE1 | Thomas, 2016 | |
| SD-Foxn1 Tg(S334ter)3LavRrrc | hESC-retina | Iraha et al., 2018 | |
| S334ter-3 | hESC-retina | MacLelland, 2018 | |
| RCS | hUTCs | Koh et al., 2018 | |
| SD-Foxn1 Tg(S334ter)3LavRrrc | hiPSC-retina | Tu et al., 2019 | |
| RCS/Laser injury in pig | hiPSC-RPE patch | Sharma et al., 2019 | |
| RCS | hiPSC-RPE cells | Shrestha, 2020 | |
| RCS | hESC-retina | Lin et al., 2020 | |
| RCS | hiPSC-RPE patch | Nair, 2021 | |
| RCS | hiPSC-RPEs/hiPSC-RPCs | Salas et al., 2021 | |
| NOD-SCID rd1/RCS | hiPSC-RPE cells/hiPSC-PR precursors | Surendran, 2021 | |
| RCS | RPC-retina | He et al., 2021 | |
| Pig | Domestic | piPSC-PR precursors | Zhou et al., 2011 |
| Yùcatan | CPCB-RPE1 | Koss et al., 2016 | |
| Large white/Landrace hybrid | hESC-RPE cells | da Cruz et al., 2018 | |
| Yùcatan | CPCB-RPE1 | Fernandes et al., 2017 | |
| RCS/laser injury in pig | hiPSC-RPE patch | Sharma et al., 2019 | |
| Monkey | Macaca fasciularis/mulatta | hESC-retina | Shirai et al., 2016 |
| Macaca fasciularis/mulatta | hESC/hiPSC-retina | Tu et al., 2019 |
3D: Three-dimensional; BMSC: bone marrow stem cell; CPCB: mesh-supported submicron parylene C membrane; hESC: human embryonic stem cell; hiPSC: human induced pluripotent stem cell; hRPC: human retinal progenitor cell; hUTC: human umbilical tissuederived cell; miPSC: mouse induced pluripotent stem cell; MSC: mesenchymal stem cell; piPSC: porcine induced pluripotent stem cell; PR: photoreceptor; RCS: Royal College of Surgeons; rd1: retinal degeneration 1; rMSC: rat mesenchymal stem cell; RPE: retinal pigment epithelial cell.