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. 2022 Nov 9;18(7):1548–1552. doi: 10.4103/1673-5374.360246

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Copyright: © Neural Regeneration Research

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Effects of DFO/Fer-1 and 3-MA on ersatin-induced ferroptosis.

(A) DFO/Fer-1 inhibits erastin-induced cell death in HT22 neurons. (B) 3-MA protects HT22 cells from erastin-induced cell death. (C) 3-MA attenuated ROS production in erastin-treated HT22 neurons. Fer-1 (20 µM), DFO (100 μM), and 3-MA (10 mM) were dissolved in dimethyl sulfoxide and added to wells immediately after erastin treatment. Each experiment was performed in triplicate. **P < 0.01, vs. control (Ctr) group; #P < 0.05, ##P < 0.01, vs. erastin group (one-way analysis of variance with Tukey’s post hoc test). DFO: Deferoxamine; Fer-1: ferrostatin 1; 3-MA: 3-methyladenin.