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. 2022 Oct 11;18(7):1512–1520. doi: 10.4103/1673-5374.355766

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Copyright: © Neural Regeneration Research

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CISD2 overexpression activates the Nrf2/HO-1 pathway in in vivo and in vitro models of CIRI.

(A–D) Representative western blots and quantitative evaluations of the effect on CISD2 overexpression on the expression of nuclear-Nrf2 and HO-1 in cerebral tissue following CIRI in mice. (E–H) Representative western blots and quantitative evaluations of the effect of CISD2 overexpression on the expression of nuclear-Nrf2 and HO-1 in OGD/R-induced HT22 cells. Data are represented as the mean ± SEM (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by Tukey’s post hoc test). CIRI: Cerebral ischemia/reperfusion injury; CISD2: CDGSH iron sulfur domain 2; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HO-1: heme oxygenase-1; I/R: cerebral ischemia/reperfusion; Nrf2: nuclear factor erythroid2-related factor 2; OGD/R: oxygen-glucose deprivation/reoxygenation.