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. 2023 Apr 5;18(4):e0283865. doi: 10.1371/journal.pone.0283865

Table 2. Health care utilizations and work incapacities associated with diagnoses of Campylobacter enteritis or sequelae over a 12-month period.

Campylobacter enteritis (CE) Sequelaea
Moderate CE (n = 6,336) Severe CE (n = 3,609) p value Reactive arthritis (n = 12) Guillain-Barré syndrome (n = 6) Crohn’s disease (n = 143) Ulcerative colitis (n = 185) Irritable bowel syndrome (n = 337)
Outpatient medical care [%]
    GP 51.7 11.9 <0.001 16.7 16.7 44.1 54.1 48.4
    pediatrician 10.5 1.2 <0.001 0.0 0.0 6.3 5.4 1.8
    internist 25.1 4.7 <0.001 8.3 66.7 38.5 30.8 43.3
    other physicians 3.9 0.6 <0.001 33.3 16.7 16.1 17.3 13.4
    provided in hospitals 0.2 0.3 0.202 0.0 16.7 6.3 4.3 2.4
Inpatient medical careb [%] 0.0 100.0 <0.001 25.0 66.7 7.7 13.0 2.1
    stays [md (min-max)] 1.0 (1.0–2.0) 1.0 (0.6–1.0) 0.7 (0.4–1.0) 0.9 (0.4–2.0) 1.0 (0.4–3.0) 1.0 (0.5–1.0)
    days per stay [md (IQR, min-max)] 5.0 (4.0–7.0, 1.0–53.0) 6.0 (4.0–22.0, 4.0–22.0) 21.0 (14.3–104.3, 13.0–131.0) 7.5 (5.3–15.8, 2.0–20.0) 8.0 (4.0–13.0, 2.0–90.0) 5.0 (3.0–5.0, 2.0–7.0)
Rehabilitation [%] 0.0 0.0 0.0 33.3 0.0 0.5 0.0
    stays [md (min-max)] 0.4 (0.4–0.4) 0.5
    days per stay [md (min-max)] 111.5 (61.0–162.0) 20.0
Prescribed medicationc [%]
    antibiotics 13.1 8.7 <0.001
    analgesics/spasmolytics 18.7 24.2 <0.001
    oral rehydration solution 1.7 1.3 0.119
Incapacities for work [%d] 18.9 57.5 <0.001 25.0 50.0 30.2 31.1 16.4
    days [md (IQR, min-max)] 8.0 (4.0–14.0, 1.0–247.0) 3.0 (1.0–7.0, 1.0–207.0) <0.001 3.0 (1.0–5.0, 1.0–5.0) 128.7 (46.0–211.4, 46.0–211.4) 5.0 (3.0–12.0, 0.6–162.0) 5.5 (2.8–13.8, 0.5–144.5) 2.0 (1.0–6.8, 0.6–38.0)

The percentage of patients utilizing the respective service or of patients who were incapacitated for work (%) and median (IQR, min-max) number of days or stays of utilizing patients are given. Existing differences or associations depending on CE severity were examined using the Wilcoxon rank-sum or Chi-square test, respectively. IQR: interquartile range, md: median.

a Average health care utilizations associated with sequelae per 12 months were determined considering the individual time between the first and the last diagnosis of the respective sequela.

b Only hospitalizations with principal diagnoses were considered to be disease-associated and are displayed.

c Considered to be CE-associated according to national medical treatment guidelines, as prescriptions of medication are not directly diagnosis-linked in the claims data.

d Proportion of patients aged 15–64 years; days refer to patients incapacitated for work according to incapacity certificates; short-term absences might not have been recorded in the claims data.