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Schematic of a novel model of combined subcortical stroke and AD. Human ApoE4-TR:5XFAD transgenic mice were subjected to an early (2 months) subcortical stroke or sham procedure. Mice were tracked over 3 months with serial motor and cognitive tasks, PET/CT, and pathological assessments to determine whether an early subcortical stroke can promote (small dashed line) or reduce (large dashed line) the progression of AD hallmarks
