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. 2023 Apr 5;9(14):eadf5583. doi: 10.1126/sciadv.adf5583

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Fig. 3. — (A) Overall structure of the FAM46A/BCCIPα-ΔL complex. Residues in the active site of FAM46A are highlighted. The structural elements in BCCIPα involved in binding to FAM46A are labeled. N and C denote the N and C termini of the proteins, respectively. (B) Structural comparison between FAM46A in the FAM46A/BCCIPα complex and FAM46C in the apo-state (PDB ID: 6W36). The structures are superimposed on the basis of the N-lobe of FAM46A and FAM46C. The dashed arrow indicates that the C-lobe of FAM46A in the complex rotates away from the N-lobe compared with that in apo-FAM46C.