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. 2023 Apr 6;12(4):259–273. doi: 10.1302/2046-3758.124.BJR-2022-0384.R1

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© 2023 Author(s) et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/

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Fig. 3 — Dihydrocaffeic acid (DHCA) increased interleukin-1β (IL-1β)-induced downregulation of anabolic mediators in mouse osteoarthritis (OA) chondrocytes. Chondrocytes were administrated with 40 μM DHCA or/and 5 ng/ml IL-1β for 24 hours. a) Western blot bands and quantitative analysis of anabolic-related proteins (aggrecan, collagen II, and SOX9). b) Quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis of anabolic-related genes (aggrecan, collagen II, and SOX9) at the mRNA expression level. c) and d) Immunofluorescence images and quantitative analysis of the expression of aggrecan and collagen II. Data were presented as means and standard deviations (n = 3). GAPDH, glyceraldehyde 3-phosphate dehydrogenase; ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001.