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. 2023 Mar 23;26(4):606–614. doi: 10.1038/s41593-023-01280-0

Fig. 3. Retina-wide receptive field architecture.

Fig. 3

a, Average spatial RFs of all RGCs pooled from square bins of 300 μm in size at different positions of one retina (n = 64 ± 52 cells per bin; black cross indicates the optic nerve head). b, Top row, optimal RFs predicted by the model at different elevations of the visual scene. Bottom row, average spatial RFs of neurons along different dorsoventral locations on the retina. c, Top, radial profiles of model RFs at different SNR levels. Bottom, mean radial profiles of RGC RFs in bins along the dorsoventral axis. d, Mean relative surround strengths of RGCs within 100-μm bins, pooled from n = 6 retinas. e, Relative surround strengths for RGCs within six equally spaced bins along the dorsoventral axis (color indicates the mean and s.e.m. pooled from n = 15,686 RFs, gray lines denote individual retinas, and the inset shows linear regression weights of RF parameter on elevation (EL) and azimuth (AZ)). f,h, Same as d, but for center size and vertical surround asymmetry, respectively. g,i, Same as e, but for center size and vertical surround asymmetry, respectively. j, Left, one of the retinas, immunostained for S-opsin. Black box shows the region imaged for RF mapping. Right, normalized histograms of surround orientations of RGCs within corresponding bins marked on the left. k, Data from h overlaid on a sinusoidal projection of visual space (n = 6 retinas). The animal is centered at 0° latitude and 0° longitude facing toward the viewer, and the black line shows the area of the visual field viewed by one eye. P values for two-sided Kolmogorov–Smirnov test: 6.11 × 10−5 (e), 2.84 × 10−4 (g) and 1.16 × 10−5 (i); see Extended Data Fig. 6 for extensive statistical comparisons). V, ventral; N, nasal; D, dorsal; T, temporal. a.u., arbitrary units.