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. 2023 Mar 15;616(7955):113–122. doi: 10.1038/s41586-023-05795-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–c, Spatial distribution and UMAP of all clusters for H3K27me3 and RNA (a), H3K27ac and RNA (b) and H3K4me3 and RNA (c) in mouse brain. Pixel size, 20 µm; scale bars, 1 mm. d, Integration of H3K27me3 data with scCUT&Tag (H3K27me3) data³⁷ from mouse brain. e, Integration of H3K27ac data with scCUT&Tag (H3K27ac) data³⁷ from mouse brain. f, Integration of RNA data in spatial CUT&Tag (H3K27me3)–RNA-seq, spatial CUT&Tag (H3K27ac)–RNA-seq and spatial CUT&Tag (H3K4me3)–RNA-seq with scRNA-seq data³² from mouse brain.