Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 22;616(7955):168–175. doi: 10.1038/s41586-023-05838-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a, FACS quantification of the percentage of active caspase-3-positive cells in YFP⁺EPCAM⁺ and YFP⁺EPCAM⁻ cells from control and 24 h cisplatin/5FU-treated SCCs. n = 9 SCCs. b,c, Microscopy analysis of the cellular density of EPCAM⁺ and EPCAM⁻ tumour cells (b) and quantification of the number of cells (c) 24 h and 48 h after cisplatin/5FU administration in vitro. Scale bar, 100 μm. n = 5 independent experiments. d, FACS quantification of the percentage of activated caspase-3-positive cells in YFP⁺EPCAM⁺ and YFP⁺EPCAM⁻ cells 24 h after cisplatin/5FU administration (n = 7); doxorubicin (n = 7), paclitaxel (n = 4), gemcitabine (n = 10), topotecan (n = 4) or etoposide (n = 6) administration; and 24 h after receiving 10 Gy irradiation. n values represent the number of biological independent experiments. For a, c and d, statistical analysis was performed using two-sided Mann–Whitney U-tests. P values were adjusted for multiple comparisons using Bonferroni correction. For the box plots, the centre line shows the median, the box limits represent the 25th and 75th percentiles, and the whiskers show the minimum and maximum values.

Source data