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. 2023 Mar 29;616(7955):143–151. doi: 10.1038/s41586-023-05869-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 12 — a: Dot plot showing normalised, log-transformed and variance-scaled expression of perivascular (PV) cell state markers. b: UMAP (uniform manifold approximation and projection) scatterplot of scRNA-seq of PV cells (n = 2768 cells) coloured by the scaled gene expression of PV cell state markers. c: (Top) High-resolution imaging of adjacent sections of maternal-fetal interface stained by multiplexed smFISH for three gene panels, from two donors. Dashed squares indicate areas shown magnified underneath (middle and below), highlighting PV1-AOC3, PV1-STEAP4, and PV2-MMP11 cells expressing each of their three respective marker genes. Solid arrows indicate relatively sparse PV1-STEAP4 cells in second and fifth columns. d: (Top) High-resolution imaging of a section of decidua stained by smFISH for HLA-G (EVTs) multiplexed with MYH11, FNDC1, and NTRK2 (PV1-AOC3); dashed squares indicate areas shown magnified below. (Middle) solid and outlined arrows indicate neighbouring PV1-AOC3 cells expressing NTRK2 and EVTs, respectively. Representative image of samples from two donors. e: (Left) High-resolution imaging of a section of decidua stained by multiplexed smFISH for HLA-G, NCAM1, and CXCL12. Dashed squares highlight arteries containing HLA-G+ NCAM1+ eEVTs expressing CXCL12, shown magnified to right. Representative image of samples from two donors.