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. 2023 Apr 5;14:1880. doi: 10.1038/s41467-023-37601-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–d Compared with control mice, CRS mice showed an increase in immobility time in a tail suspension test (TST) (n = 11 and 13 mice per group for no-stress and CRS, respectively, Unpaired t test, p = 0.00001, t(22) = 5.674) (a), without changes in the total distance traveled in an open field test (OFT) (n = 11 and 13 mice per group for no-stress and CRS, respectively, Unpaired t test, p = 0.8169, t(22)=0.2343) (b). CRS mice spent similar time in the center area of the OFT (n = 11 and 13 mice per group for no-stress and CRS, respectively, Mann-Whitney test, p = 0.0821, U = 41) (c) and in the open arms of an elevated O-maze test (n = 11 and 13 mice per group for no-stress and CRS, respectively, Unpaired t test, p = 0.1165, t(22) = 1.634) (d). e, f Representative Western blot and quantification of A_2AR protein levels in the septum (n = 6 mice/group, Unpaired t test, p = 0.0050, t(10) = 3.584), striatum (n = 6 mice/group, Unpaired t test, p = 0.9898, t(10) = 0.01314), prefrontal cortex (PFC) (n = 6 mice/group, Unpaired t test, p = 0.08, t(10) = 1.948) and hippocampus (n = 6 mice/group, Unpaired t test, p = 0.0886, t(10) = 1.886) of CRS and control mice. CRS mice displayed a selective upregulation of A_2AR in the septum without significant changes in the other three brain regions associated with mood processing. Data were shown as mean ± SEM. **p < 0.01, ***p < 0.001; n.s., no significant difference. Source data are provided as a Source Data file.