Table 1.
Clinical characteristics of study cohorts by clinical status.
| Characteristics | NIDDK | Optum | |||
|---|---|---|---|---|---|
| NASH (n = 181) |
Non-NASH (n = 100) |
NASH (n = 1016) |
ICD-10 NASH (n = 21,930) |
Undiagnosed NASH (n = 2,886,653) |
|
| Age, mean ± SD | 48.6 ± 10.4 | 48.2 ± 9.4 | 55.5 ± 12.6 | 57.3 ± 13.2 | 61.2 ± 15.3 |
| Female, N (%) | 124 (69%) | 52 (52%) | 663 (65%) | 13,168 (60%) | 1,544,078 (53%) |
| T2DM, N (%) | 84 (46%) | 28 (28%) | 721 (71%) | 14,916 (68%) | 1,532,744 (53%) |
| Hypertension, N (%) | 101 (56%) | 44 (44%) | 805 (79%) | 16,948 (77%) | 2,253,961 (78%) |
| Hyperlipidemia, N (%) | 110 (61%) | 53 (53%) | 803 (79%) | 17,558 (80%) | 2,101,467 (73%) |
| BMI, mean ± SD | 33.8 ± 5.2 | 33.4 ± 6.0 | 34.8 ± 7.3 | 35.5 ± 8.1 | 32.7 ± 45.2 |
| HbA1c, mean ± SD | 6.6 ± 1.8 | 5.8 ± 1.0 | 6.7 ± 1.6 | 6.7 ± 1.6 | 6.6 ± 16.0 |
NIDDK: National Institute of Diabetes and Digestive Kidney Diseases; NASH: biopsy-confirmed NASH; Non-NASH: biopsy-confirmed non-NASH; ICD-10 NASH: patient coded for NASH, no biopsy reading; undiagnosed NASH: patients with no records of NASH by coding or liver biopsy; T2DM: type 2 diabetes mellitus; BMI: body mass index; HbA1c: glycated hemoglobin.