Table 4.
Features of patients correctly classified and misclassified by NASHmap in NIDDK.
| NASHmap featurea | Biopsy-confirmed NASH | Biopsy-confirmed non-NASH | ||||
|---|---|---|---|---|---|---|
| True positive (n = 147) | False negative (n = 34) | P-value | True negative (n = 63) | False positive (n = 37) | P-value | |
| HbA1c (%) | 6.72 ± 2.09 | 6.04 ± 1.64 | 0.04 | 5.53 ± 0.85 | 6.13 ± 1.23 | 0.01 |
| AST (U/L) | 75.88 ± 49.64 | 34.94 ± 16.20 | < 0.01 | 38.12 ± 20.11 | 53.76 ± 21.43 | < 0.01 |
| ALT (U/L) | 104.09 ± 52.77 | 47.99 ± 44.08 | < 0.01 | 44.77 ± 20.62 | 82.57 ± 55.55 | < 0.01 |
| Total protein (g/dL) | 7.46 ± 0.61 | 7.15 ± 0.47 | < 0.01 | 7.07 ± 0.48 | 7.36 ± 0.68 | 0.03 |
| AST/ALT | 0.82 ± 0.30 | 0.94 ± 0.48 | 0.16 | 0.94 ± 0.45 | 0.77 ± 0.30 | 0.02 |
| BMI | 33.42 ± 4.68 | 35.49 ± 6.88 | 0.87 | 33.51 ± 6.22 | 33.25 ± 5.60 | 0.17 |
| TG (mg/dL) | 219.09 ± 147.20 | 205.53 ± 144.93 | 0.63 | 148.85 ± 75.00 | 156.87 ± 103.04 | 0.68 |
| Height (cm) | 167.00 ± 8.17 | 167.83 ± 9.57 | 0.87 | 167.83 ± 7.21 | 166.72 ± 9.71 | 1.00 |
| PLT (× 103/μL) | 237.63 ± 77.39 | 225.08 ± 73.34 | 0.36 | 247.09 ± 72.05 | 251.08 ± 67.56 | 0.78 |
| WBC (× 103/μL) | 7.03 ± 2.04 | 7.25 ± 2.12 | 0.58 | 6.55 ± 1.59 | 6.83 ± 2.12 | 0.47 |
| Hematocrit (%) | 41.99 ± 4.24 | 41.87 ± 3.60 | 0.87 | 41.86 ± 3.52 | 41.44 ± 3.39 | 0.56 |
| Albumin (g/dL) | 4.37 ± 0.36 | 4.09 ± 0.34 | < 0.01 | 4.19 ± 0.41 | 4.33 ± 0.34 | 0.07 |
| Hypertension, n (%) | 81 (55.10%) | 20 (58.82%) | 0.84 | 30 (47.62%) | 14 (37.84%) | 0.46 |
| Female, n (%) | 105 (71.43%) | 21 (61.76%) | NA | 32 (50.79%) | 19 (51.35%) | NA |
NIDDK: National Institute of Diabetes and Digestive Kidney Diseases; NASH: nonalcoholic steatohepatitis; HbA1c: glycated hemoglobin; AST: aspartate transaminase, ALT: alanine transaminase; BMI: body mass index; TG: triglycerides; PLT: platelets; WBC: white blood cells.
aFeatures are listed by decreasing order of predictive importance in the model. Data are presented as mean ± SD unless otherwise stated.