Table 5.
Clinical features of Optum real-world database patients predicted as NASH or non-NASH by NASHmap.
| NASHmap feature | Biopsy-confirmed NASH | Undiagnosed | ||||||
|---|---|---|---|---|---|---|---|---|
| True positive (n = 727) | %ONR | False negative (n = 289) | %ONR | Predicted NASH (n = 883,867) | %ONR | Predicted non-NASH (n = 2,002,786) | %ONR | |
| HbA1c (%) | 6.98 ± 1.62 | 81 | 6.03 ± 1.45 | 49 | 7.06 ± 1.72 | 87 | 6.31 ± 1.53 | 63 |
| AST (U/L) | 63.63 ± 81.18 | 69 | 27.63 ± 19.85 | 16 | 41.21 ± 144.28 | 28 | 21.27 ± 35.24 | 3 |
| ALT (U/L) | 72.22 ± 59.19 | 76 | 30.55 ± 22.93 | 25 | 42.44 ± 99.86 | 41 | 23.35 ± 28.51 | 11 |
| Total protein (g/dL) | 7.35 ± 0.6 | 17 | 6.94 ± 0.63 | 8 | 7.28 ± 3.23 | 13 | 6.95 ± 1.42 | 6 |
| AST/ALT | 0.96 ± 0.46 | 32 | 1.00 ± 0.48 | 39 | 1.08 ± 0.64 | 43 | 1.03 ± 0.65 | 41 |
| BMI | 35.36 ± 7.14 | ND | 33.26 ± 7.62 | ND | 34.43 ± 8.18 | ND | 31.80 ± 7.91 | ND |
| TG (mg/dL) | 200.99 ± 171.42 | 23 | 152.35 ± 263.85 | 8 | 197.16 ± 177.68 | 22 | 131.53 ± 100.02 | 6 |
| Height (cm) | 167.46 ± 9.67 | NA | 168.07 ± 10.24 | NA | 168.56 ± 10.62 | NA | 168.92 ± 10.71 | NA |
| PLT (× 103/μL) | 213.76 ± 81.6 | 21 | 221.44 ± 87.32 | 20 | 240.08 ± 76.36 | 8 | 244.12 ± 73.59 | 7 |
| WBC (× 103/μL) | 7.42 ± 2.5 | 14 | 6.75 ± 2.49 | 10 | 8.47 ± 3.92 | 22 | 7.51 ± 3.32 | 13 |
| Hematocrit (%) | 40.37 ± 4.96 | 13 | 39.01 ± 5.87 | 16 | 40.77 ± 5.42 | 12 | 39.89 ± 5.19 | 12 |
| Albumin (g/dL) | 4.01 ± 0.54 | 14 | 3.88 ± 0.62 | 23 | 4.05 ± 4.33 | 11 | 3.92 ± 5.08 | 17 |
| Hypertension, n (%) | 590 (81.16%) | NA | 215 (74.39%) | NA | 723,571 (81.86%) | NA | 1,530,390 (76.41%) | NA |
| Female, n (%) | 476 (65.47%) | NA | 187 (64.71%) | NA | 460,981 (52.16%) | NA | 1,083,097 (54.08%) | NA |
Data are presented as mean ± SD unless otherwise stated.
NASH: nonalcoholic steatohepatitis; %ONR: % out of normal range; ND: not determined; NA: not applicable; HbA1c: glycated hemoglobin; AST: aspartate transaminase, ALT: alanine transaminase; BMI: body mass index; TG: triglycerides; ONR: outside normal range; PLT: platelets; WBC: white blood cells.