Table 6.
Profile of patients with biopsy-confirmed NASH and predicted NASH in an Optum database T2DM cohort.
| NASHmap feature | T2DM + confirmed NASH (n = 721) | %ONR | T2DM + predicted NASH (n = 585,272) | %ONR |
|---|---|---|---|---|
| HbA1c (%) | 7.17 ± 1.71 | 84 | 7.66 ± 1.77 | 96 |
| AST (U/L) | 53.03 ± 78.22 | 53 | 40.09 ± 175.92 | 26 |
| ALT (U/L) | 57.24 ± 51.33 | 60 | 40.52 ± 96.02 | 39 |
| Total protein (g/dL) | 7.21 ± 0.63 | 13 | 7.26 ± 7.48 | 12 |
| AST/ALT | 0.99 ± 0.46 | 37 | 1.07 ± 0.64 | 43 |
| BMI | 35.09 ± 7.40 | 74 | 34.75 ± 28.50 | 71 |
| TG (mg/dL) | 196.93 ± 232.16 | 19 | 208.48 ± 697.51 | 24 |
| Height (cm) | 167.25 ± 9.83 | NA | 168.78 ± 10.66 | NA |
| PLT (× 103/μL) | 208.29 ± 86.68 | 25 | 238.66 ± 147.18 | 8 |
| WBC (× 103/μL) | 7.26 ± 2.54 | 13 | 8.57 ± 7.48 | 23 |
| Hematocrit (%) | 39.49 ± 5.30 | 16 | 40.63 ± 26.38 | 12 |
| Albumin (g/dL) | 3.93 ± 0.58 | 18 | 4.02 ± 5.13 | 11 |
| Hypertension, n (%) | 623 (86.41%) | NA | 502,466 (85.85%) | NA |
| Female, n (%) | 476 (66%) | NA | 296,032 (51%) | NA |
Data are presented as mean ± SD unless otherwise stated.
NASH: nonalcoholic steatohepatitis; HbA1c: glycated hemoglobin; AST: aspartate transaminase, ALT: alanine transaminase; BMI: body mass index; NA: not applicable; ONR: outside normal range; PLT: platelets; T2DM: type 2 diabetes mellitus; TG: triglycerides; WBC: white blood cells.