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. 2023 Apr 5;14:1884. doi: 10.1038/s41467-023-37253-x

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© The Author(s) 2023, corrected publication 2023

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Fig. 1 — A Boron neutron capture reaction (BNCR) occurs when ¹⁰B is irradiated with thermal neutrons, yielding fatal and high-energy alpha particles (⁴He) and lithium-7 nuclei (⁷Li). B High-energy nuclei from BNCR break boron capsule through inelastic collisions. The resulting secondary ions develop more defects in the framework and therefore construct additional channels for faster drug release. C Schematic representation of the synthesis of carborane-derived covalent organic framework (B-COF) by the condensation of 1,3,5-tris(4-aminophenyl)-benzene (TAPB) and p-carborane-1,10-phenyl-dialdehyde (B-CHO) under an optimized condition. D Powder X-ray diffraction (PXRD) patterns of the experimentally observed (red curve), Pawley refined (grey curve) B-COF and an eclipsed AA stacking mode (blue curve) (their difference is shown in the green curve). The inset shows reconstructed structure of AA stacking layered framework of B-COF at top view and side view, respectively. E Large-scale transmission electron microscopy (TEM) of B-COF with uniform morphology. F, G TEM image of B-COF showing hexagonal pores. Inset of panel G is the fast Fourier transform (FFT) from the orange square marked area. H Lattice fringe distance measurement of the marked area in panel H showing the average lattice distance of B-COF. I, J TEM (I) and the energy dispersive spectroscopy (EDS) elemental mapping images of carbon (J) or boron(K) of B-COF. L, Fourier transform infrared spectra (FTIR) of B-COF and the corresponding building blocks (n = 3 samples), respectively. M Nitrogen adsorption (solid dots)-desorption (hollow dots) isotherms at 77 K of B-COF and drug-loaded B-COF (n = 3 samples). N Thermogravimetric analysis (TGA) curves of B-COF and drug-loaded B-COF (n = 3 samples). O Hydrodynamic size and zeta potential (n = 3 samples) of the boron capsule (the PEGylated drug-loaded B-COF). The experiments for E–K were repeated three times independently (n = 3 samples) with similar results. Data are presented as mean ± SD (O). Source data are provided as a Source Data file.