Table 2.
Electrophysiological properties of hiPSC-CM in engineered heart muscle
| Lemoine et al. [46] | Lemoine et al. [45] | Horváth et al. [25] | Tiburcy et al. [68] | |
|---|---|---|---|---|
| Capacitance (pF) | 28 | 47 | ||
| INa | ||||
| Peak INa density | − 19 | |||
| Potential | − 30 | |||
| [Na]i for Peak INa (mM) | 5 | |||
| [Na]e for Peak INa (mM) | 5 | |||
| Temperature (°C) | 20 | |||
| Erev (mV) | 0 | |||
| Conductance (S/F) | 633 | |||
| ICa,L | ||||
| ICa,L density | ||||
| Temperature (°C) | ||||
| IK1 | ||||
| IK1 density (pA/pF) | − 14 | |||
| Step potential | − 100 | |||
| [K]i for IK1 (mM) | 150 | |||
| [K]e for IK1 (mM) | 20 | |||
| Temperature (°C) | 20 | |||
| Erev (mV) | − 51 | |||
| Conductance (S/F) | 285 | |||
| IKr | ||||
| IKr tail (pA/pF) | ||||
| IKr step (pA/pF) | ||||
| Temperature (°C) | ||||
| Action Potential | ||||
| RMP (mV) | − 78 | − 78 | − 75 | − 72 |
| dV/dtmax (V/s) | 219 | 348 | 107 | |
| APA (mV) | 103 | 109 | 97 | |
| APD90 (ms) | NA | 255 | 271 | 436 |
| Frequency (Hz) | 1 | 1 | 1 | Spontaneous |
| Temperature (°C) | 37 | 37 | 37 | 37 |
| Days after differentiation onset | 42 | 39–114 | 42 | NA |
Currents are dependent on ion concentrations, which differ between studies. Be cautious with direct comparisons which should ideally be made between groups studies under identical conditions