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. 2023 Apr 5;13:5583. doi: 10.1038/s41598-023-32682-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Social conditioned place preference. (a–b) The change in preference for the social context after 6 days of conditioning in female and male mice, respectively. Each pair of points represents an individual animal, and the group sizes are indicated below the graphs. A significant difference between the pre- and posttests (30 min) is marked with a “*” (paired t-test, p < 0.05). (c) No difference between females and males preference score [s], calculated as time spent in social context posttest [s] minus time spent in in isolate context posttest [s]. Each point represents an individual female or male mouse, with the mean and s.e.m. shown in black and the group sizes indicated below. A significant preference (greater than 0) is indicated by a “‡” (one-sample t-test p < 0.05). (d) No significant change in preference for the social context after 2 days of conditioning in male mice. (e) The preference score for social context during the posttest after 2 days of conditioning. The group sizes are indicated below the graph.