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. 2023 Mar 23;14:1070426. doi: 10.3389/fphys.2023.1070426

FIGURE 1.

FIGURE 1

Precocious pubertal development occurs in the preeclamptic-like BPH/5 female offspring. (A) Age at the day of vaginal opening in BPH/5 and C57 female offspring (n = 16–19/group, Student’s t-test, mean ± SEM, *p < 0.0001). (B) Body weight (BW) at the day of vaginal opening in peripubertal BPH/5 and C57 female offspring (n = 16–19/group, Student’s t-test, mean ± SEM, *p < 0.0001). (C) A negative correlation occurs between BW and age at vaginal opening in BPH/5 females (n = 19, Simple linear regression with 95% confidence bands of best-fit line, p = 0.0052), while a significant correlation was not seen in C57 controls (n = 16, Simple linear regression with 95% confidence bands of best-fit line, p = 0.1974). (D) Reproductive white adipose tissue weight corrected to BW (rWAT/BW ratio) in peripubertal BPH/5 and C57 females at the day of vaginal opening (n = 16–19/group, Student’s t-test, mean ± SEM, p = 0.1549).