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. 2023 Mar 23;14:1070426. doi: 10.3389/fphys.2023.1070426

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Copyright © 2023 Gomes, Beckers, Crissman, Landry, Flanagan, Awad, Piero, Liu and Sones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Precocious pubertal development does not occur in BPH/5 male offspring. (A) Age at the day of balanopreputial separation in peripubertal BPH/5 and C57 male offspring (n = 7–11/group, Student’s t-test, mean ± SEM, p = 0.8923). (B) Serum testosterone concentration in peripubertal and adult BPH/5 and C57 males (n = 3–9/group, Two-way ANOVA, post hoc Tukey’s test, mean ± SEM, *p = 0.0278 in adult BPH/5 vs. peripubertal BPH/5). (C) Combined testicular weight (i.e., both testes) corrected by body weight (Testicular weight/BW ratio) in adult BPH/5 males and age matched C57 (n = 8–17/group, Student’s t-test, mean ± SEM, p = 0.455).