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. 2023 Mar 23;14:1070426. doi: 10.3389/fphys.2023.1070426

FIGURE 3.

FIGURE 3

Female BPH/5 offspring present hyperandrogenism during adulthood, which is attenuated by dietary weight loss. (A) Reproductive tract wet weight corrected to body weight (BW) in peripubertal BPH/5 and C57 females (n = 16–19/group, Student’s t-test, mean ± SEM, *p = 0.0006). (B,C) As previously reported (Sutton et al., 2017), adult ad libitum-fed BPH/5 females (BPH/5 AL) present lower serum 17β-estradiol and similar uterine wet weight to ad libitum-fed C57 (C57 AL) during proestrus. In this study, (B) reproductive tract/body weight ratio and (C) serum 17β-estradiol were unchanged in proestrual pair-fed BPH/5 females (BPH/5 PF) vs. BPH/5 AL females (n = 4–8/group, One-way ANOVA and post hoc Tukey’s test, mean ± SEM, *p < 0.05 vs. C57 AL). (D) Serum testosterone concentration was below the assay detection limit of 2 ng/dL in proestrual C57 AL. Serum testosterone concentration was detected in proestrual BPH/5 AL females and was attenuated in BPH/5 PF females (n = 3–4/group, Student’s t-test, mean ± SEM, *p = 0.0473).