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. 2023 Mar 23;14:1161960. doi: 10.3389/fimmu.2023.1161960

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Copyright © 2023 Tan, Pan, Deng, Chen, Xia, Liu, Zou and Qin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MGLL affects macrophage polarization in the TME. (A) Distribution of different cell clusters in the UMAP plot. (B) The fraction of each sample depends on the type of cell. (C) MGLL expression in distinct clusters of cells. (D) Correlation analysis between expression of MGLL in cancer cells and composition of infiltrating macrophages (SPP1-ACP5). (E) THP-1 macrophages were polarized towards an M1-like phenotype by the conditioned media of ARPE-19 cells with reduced MGLL expression. (F) THP-1 macrophages were polarized to an M2-like phenotype by the conditioned medium of MuM-2B cells with highly expressed MGLL. (n = 3, paired Student’s t-test) **p < 0.01; ***p < 0.001; ****p < 0.0001 ns, no significance.