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. 2023 Mar 23;14:1004795. doi: 10.3389/fimmu.2023.1004795

Table 1.

Administration route and dosing regimens of anti-CD20 mAbs in phase II/III clinical trials.

Administration route Rituximab
(OLYMPUS)
Rituximab
(RIFUND-MS)
Ocrelizumab
(OPERA I/II)
Ofatumumab
(ASCLEPIOS I/II)
Ublituximab
(ULTIMATE I/II)
IV infusion IV infusion IV infusion SC self-injection IV infusion
Dosing regimen
First dose 1 000 mg 1 000 mg 2 x 300 mg over ≥ 2.5 h 20 mg 150 mg over 4 h
Second dose and timing 1 000 mg at
week 2
2 x 300 mg over ≥ 2.5 h at week 2 20 mg at weeks 1 and 2 450 mg over 1 h on day 15
Subsequent doses and timing 1 000 mg every 6 months 500 mg every 6 months 600 mg over ≥ 3.5 h or over ≥ 2 h every 6 months Every month starting at week 4 450 mg over 1 h at weeks 24, 48 and 72

IV, intravenous; SC, subcutaneous.