Table 4.

Antiepileptic drug characteristics

Characteristics	IDHwt hLGG n = 50	IDHwt glioblastoma n = 129	Total epilepsy cohort n = 179	P-Value
First AED ≤ 2014, no. (%)a	31 (63%)	40 (33%)	71 (42%)	<.001
Polytherapy, no. (%)	16 (32%)	22 (17%)	48 (27%)	.028
Type of first AED				<.001
Levetiracetam, no. (%)	22 (44%)	91 (71%)	113 (63%)
Valproic acid, no. (%)	19 (38%)	29 (23%)	48 (27%)
Other, no. (%)	8 (16%)	4 (3%)	12 (7%)
Clonazepam	0 (0%)	1 (1%)	1 (1%)
Phenytoin	1 (2%)	1 (1%)	2 (1%)
Clobazam	0 (0%)	1 (1%)	1 (1%)
Carbamazepine	4 (8%)	0 (0%)	4 (2%)
Phenytoin	2 (4%)	0 (0%)	2 (1%)
Lamotrigine	1 (2%)	0 (0%)	1 (1%)
Unknown	0 (0%)	1 (1%)	1 (1%)

Abbreviations: AED, antiepileptic drug; IDHwt hLGG, IDHwt glioma WHO grade 2 and 3 with molecular glioblastoma-like profile; no., number of patients.

^aCut-off based on changed policies as a result of updated evidence.²⁰