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. 2022 Oct 10;25(4):786–798. doi: 10.1093/neuonc/noac219

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Fig. 4 — Spatial transcriptomics delineates distinct stages of EMT in PFA. (A) Representative spatial arrangement of mesenchymal zone subclusters in PFA samples. (B) Top GO term geneset enrichments [hypergeometric test FDR (−log10)] for mesenchymal zone subclusters. (C) Representative histology of mesenchymal zone subclusters. (D) Heatmap of average individual cluster spot (y-axis) distances (mm) to nearest other cluster (x-axis). (E) Representative spatial gene expression of key markers of MEC-A (SERPINA3) and MEC-D (VEGFA). (F) Heatmap of differentially expressed genes between UEC-A and UEC-B clusters. CEC, ciliated EPN cells; TEC, transportive EPN cells; UEC, undifferentiated EPN cells; MEC, mesenchymal EPN cells.