Table 3.

Comparison of neurological symptoms and sleep disturbance during acute COVID-19.

	Neurological symptoms		P-value*	Sleep disturbance		P-value**
	No	Yes		No	Yes
	(n = 16)	(n = 15)		(n = 13)	(n = 17)
	Median (IQR)	Median (IQR)		Median (IQR)	Median (IQR)
Neopterin [nmol/L]	42.5 (16.0-47.6)	24.9 (18.3-36.6)	n.s.	32.6 (17.1-43.6)	24.9 (17.3-45.1)	n.s.
Kyn [µmol/L]	3.4 (2.4-3.9)	3.4 (1.9-4.3)	n.s.	3.7 (2.5-4.1)	3.1 (2.1-3.9)	n.s.
Trp [µmol/L]	43.1 (38.4-51.9)	51.3 (35.7-53.6)	n.s.	51.8 (43.1-53.9)	42.2 (34.8-51.4)	.046
Phe [µmol/L]	131.6 (121.4-151.3)	120.5 (112.0-130.0)	n.s.	128.8 (117.9-132.0)	122.6 (98.2-153.6)	n.s.
Tyr [µmol/L]	62.6 (60.2-77.9)	70.9 (57.9-73.4)	n.s.	68.2 (58.7-73.3)	63.5 (58.0-81.3)	n.s.
Kyn/Trp [µmol/mmol]	68.1 (57.3-96.7)	66.7 (47.5-89.6)	n.s.	69.1 (48.7-87.2)	63.2 (52.6-94.1)	n.s.
Phe/Tyr [µmol/µmol]	2.0 (1.55-2.2)	1.8 (1.6-2.0)	n.s.	2.0 (1.8-2.1)	1.7 (1.5-2.2)	n.s.
Nitrite [µmol/L]	22.9 (11.6-33.7)	22.4 (13.3-44.0)	n.s.	28.3 (13.4-43.7)	20.4 (9.3-34.5)	n.s.
CRP [mg/dL]	3.46 (2.18-14.17)	16.37 (10.93-21.53)	0.053	3.5 (1.1-9.9)	16.37 (11.88-20.92)	.018
IL-6 [ng/L]	41.5 (14.2-135.0)	118.1 (42.0-230.2)	n.s.	41.6 (9.9-93.1)	130.8 (48.7-331.2)	.009

Median values and IQR of study parameters during acute COVID-19.

^*P-value comparing the 2 groups of the categorical variable neurological symptoms.

^**P-value comparing the 2 groups of the categorical variable sleep disturbance; no significant difference (n.s.).

Lab parameters printed in bold differed significantly between patients with/without sleep disturbance.