Table 4.
Comparison of neurological symptoms, fatigue, and sleep disturbance at the follow-up (FU).
| Neurological symptoms | P-value* | Fatigue | P-value** | Sleep disturbance | P-value*** | ||||
|---|---|---|---|---|---|---|---|---|---|
| No | Yes | No | Yes | No | Yes | ||||
| (n = 24) | (n = 5) | (n = 14) | (n = 15) | (n = 19) | (n = 10) | ||||
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | ||||
| Neopterin [nmol/L] | 10.2 (8.0-16.6) | 8.4 (7.3-8.6) | .073 | 9.0 (7.9-13.5) | 9.3 (8.0-17.4) | n.s. | 8.9 (8.0-14.0) | 10.2 (8.3-14.1) | n.s. |
| Kyn [µmol/L] | 2.3 (2.0-2.8) | 1.8 (1.6-2.6) | n.s. | 2.4 (1.9-3.2) | 2.2 (1.9-2.4) | n.s. | 2.3 (2.0-3.0) | 2.3 (1.9-2.5) | n.s. |
| Trp [µmol/L] | 53.6 (47.4-58.9) | 63.1 (50.3-75.7) | n.s. | 54.5 (46.1-60.0) | 52.8 (51.7-63.1) | n.s. | 54.4 (51.9-63.1) | 52.5 (42.8-57.5) | n.s. |
| Phe [µmol/L] | 68.4 (61.4-81.9) | 69.9 (64.8-84.4) | n.s. | 70.1 (62.2-89.1) | 67.9 (62.7-73.9) | n.s. | 70.9 (63.1-89.4) | 67.0 (59.2-70.5) | .081 |
| Tyr [µmol/L] | 59.0 (52.9-74.1) | 67.2 (55.7-98.1) | n.s. | 64.3 (52.5-76.3) | 58.3 (54.2-70.5) | n.s. | 58.3 (54.0-74.5) | 59.7 (52.7-69.5) | n.s. |
| Kyn/Trp [µmol/mmol] | 43.1 (36.8-56.7) | 34.4 (28.2-36.1) | .015 | 44.8 (35.4-58.9) | 39.3 (34.4-45.5) | n.s. | 40.0 (33.7-55.1) | 40.9 (36.4-56.5) | n.s. |
| Phe/Tyr [µmol/µmol] | 1.1 (1.0-1.4) | 1.0 (0.9-1.2) | n.s. | 1.1 (1.0-1.4) | 1.0 (0.96-1.3) | n.s. | 1.1 (1.0-1.4) | 1.0 (0.9-1.2) | n.s. |
| Nitrite [µmol/L] | 24.8 (11.1-54.8) | 42.9 (16.9-100) | n.s. | 34.6 (11.9-97.9) | 22.6 (11.2-52.4) | n.s. | 41.2 (16.8-100) | 13.3 (9.3-27.5) | .017 |
| CRP [mg/dL] | 0.16 (0.06-0.52) | 0.26 (0.1-2.5) | n.s. | 0.12 (0.06-0.21) | 0.39 (0.07-1.75) | 0.055 | 0.13 (0.06-0.38) | 0.49 (0.11-1.91) | .060 |
| IL-6 [ng/L] | 2.5 (1.5-5.2) | 8.5 (1.5-23.2) | n.s. | 1.7 (1.5-4.9) | 4.8 (1.5-12.7) | n.s. | 1.8 (1.5-5.1) | 5.3 (1.5-13.5) | n.s. |
Median values and IQR of study parameters at FU.
*
P-value comparing the 2 groups of the categorical variable neurological symptoms at FU.
**
P-value comparing the 2 groups of the categorical variable fatigue at FU.
***
P-value comparing the 2 groups of the categorical variable sleep disturbance at FU; no significant difference (n.s.).
Lab parameters printed in bold differed significantly between patients with/without neurological symptoms.