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. 2023 Mar 15;13(3):1004–1025.

Figure 2.

Figure 2

SPARC/MMP9/CD44 signature is overexpressed in HNSCC and linked to progression. Expression levels of (A) Venn diagram of 3 selected overexpressed overlapping DEGs. (B) Overexpression of SPARC/MMP9/CD44 oncogenes in tumor tissues compared to normal tissues. (C-E) SPARC/MMP9/CD44 were more expressed in stage II to stage IV on HNSCC than in stage I. The transcript levels of (F) SPARC, (G) MMP9, and (H) CD44 were significantly overexpressed in tumors starting from grade 1 to grade 4 as compared to normal tissue. The numbers in parenthesis in (F-H) indicate sample numbers, and a P-value less than 0.05 is considered statistically significant SPARC (G1: P = 1.62 × 10-6, G2: P = 1.60 × 10-7, G3: P = 1.15 × 10-8 and G4: P = 1.62 × 10-12). MMP9: (G1: P = 2.31 × 10-5, G2: P = 2.51 × 10-6, G3: P = 1.98 × 10-7 and G4: P = 1.62 × 10-12) CD44: (G1: P = 1.16 × 10-7, G2: P = 2.55 × 10-10, G3: P = 1.76 × 10-10 and G4: P = 1 × 10-12).