Table 3.
Activated Cellular Component in EMosis-CC/TERT1 cells treated with 5 μM TPEN
| Enrichment FDR | Genes in list | Functional Category | Genes |
|---|---|---|---|
| 6.44E-10 | 140 | Nucleoplasm | AFF4 EED ZBTB25 FBL KDM4C MYCT1 KDM6B MED10 SAP130 KANSL1L TRMT10A POLR2H SAP30 JUNB HDAC3 JUN HEXIM1 ZNF407 KDM7A BIRC3 ATP6V0A1 USP28 RRM2B MXD1 CTDP1 JMJD6 P4HA2 PIAS2 ALKBH5 SNAP23 BTAF1 RBFOX2 TRMU RNMT POLI NXT2 USP11 KLF5 HCFC1R1 IMPAD1 UBXN8 BNIP3L ZNF175 HBP1 PLEKHA8 SHB ACBD5 PTGES3 KDM3A ABCB6 CACYBP GADD45A HSPH1 ATF1 NQO2 OARD1 STK35 ZBTB1 THOC6 SLX1A USPL1 BHLHE40 HILPDA TXNL4B EIF4A3 CTSK PIP5K1A EAF1 FEM1C TNIP1 RBAK POMZP3 NPAT IPMK LSM11 FBXO32 EMSY RUNX1 CHTOP RYBP YEATS2 PCF11 RAB8B MAPK7 POLR3D ING2 UBE2V2 MAP3K2 PFKFB3 MLLT3 NMNAT1 CSTF3 SERTAD2 SIAH2 C11ORF54 SP1 STK40 POM121 LONP1 XRCC2 ADARB1 FANK1 HSPA1B HSPA1A PPP1R10 SRA1 ZNF432 ETV3 GZF1 THAP1 ASCC1 CIART PPID BNIP3 ARL6IP4 SNAPC1 NEDD4L RORA HSP90AA1 TRMT6 NR4A3 NR4A1 SNAI1 UPF3B IPPK EGLN3 DNAJB1 USP37 CENPO ANP32A ESCO1 SMYD2 METTL21A NOCT ATF3 DDIT3 IMP3 MAFF TRIM33 PPME1 |
| 4.06E-09 | 164 | Nuclear part | SNAPC1 SPAG4 AFF4 EED ZBTB25 NXT2 BNIP3L FBL KDM4C MYCT1 UPF3B PRKRIP1 KDM6B MED10 SAP130 CENPO NUP58 TXNL4B KANSL1L TRMT10A LSM11 POLR2H SAP30 POLR3D JUNB HDAC3 HSPA6 DDIT3 BNIP3 JUN IMP3 SPTY2D1 HEXIM1 POM121 ADARB1 SMG5 HSPA1B HSPA1A ZNF407 POM121C KDM7A BIRC3 ATP6V0A1 USP28 RRM2B MXD1 CTDP1 JMJD6 P4HA2 PIAS2 ALKBH5 SNAP23 BTAF1 SCD RBFOX2 TRMU RNMT POLI USP11 KLF5 HCFC1R1 IMPAD1 UBXN8 ZNF175 HBP1 PLEKHA8 SHB ACBD5 PTGES3 PARP11 KDM3A ABCB6 CACYBP GADD45A MXI1 HSPH1 ATF1 NR4A1 NQO2 OARD1 GZF1 STK35 ZBTB1 THOC6 THAP1 SLX1A WBP2 USPL1 BHLHE40 HILPDA DNAJB2 MFAP1 SLC16A3 EIF4A3 CTSK PIP5K1A EAF1 FEM1C TNIP1 RBAK POMZP3 NPAT IPMK PDK1 FBXO32 EMSY RUNX1 CHTOP ATF3 RYBP YEATS2 PCF11 RAB8B MAPK7 ING2 UBE2V2 ZEB2 MAP3K2 PFKFB3 PPID MLLT3 NMNAT1 CSTF3 SERTAD2 SIAH2 C11ORF54 DDX41 SP1 STK40 LONP1 XRCC2 FANK1 PPP1R10 SRA1 ZNF432 FAM156A GMCL1 RGS2 ETV3 HSPA2 DNAJB9 DNAJB1 ASCC1 AGPAT5 CIART ERN1 ARL6IP4 IPPK NEDD4L RORA HSP90AA1 TRMT6 NR4A3 SNAI1 EGLN3 USP37 ANP32A ESCO1 SMYD2 METTL21A NOCT MAFF TRIM33 PPME1 |
| 1.78E-08 | 151 | Nuclear lumen | AFF4 EED ZBTB25 FBL KDM4C MYCT1 UPF3B PRKRIP1 KDM6B MED10 SAP130 CENPO KANSL1L TRMT10A POLR2H SAP30 JUNB HDAC3 JUN IMP3 SPTY2D1 HEXIM1 ADARB1 ZNF407 KDM7A BIRC3 SNAPC1 ATP6V0A1 USP28 RRM2B MXD1 CTDP1 JMJD6 P4HA2 PIAS2 ALKBH5 SNAP23 BTAF1 SCD RBFOX2 TRMU RNMT POLI NXT2 USP11 KLF5 HCFC1R1 IMPAD1 UBXN8 BNIP3L ZNF175 HBP1 PLEKHA8 SHB ACBD5 PTGES3 KDM3A ABCB6 CACYBP GADD45A MXI1 HSPH1 ATF1 NQO2 OARD1 GZF1 STK35 ZBTB1 THOC6 THAP1 SLX1A WBP2 USPL1 BHLHE40 HILPDA TXNL4B EIF4A3 CTSK PIP5K1A EAF1 FEM1C TNIP1 RBAK POMZP3 NPAT IPMK PDK1 LSM11 FBXO32 EMSY RUNX1 CHTOP ATF3 RYBP YEATS2 PCF11 RAB8B MAPK7 POLR3D ING2 UBE2V2 ZEB2 MAP3K2 PFKFB3 PPID MLLT3 NMNAT1 CSTF3 SERTAD2 SIAH2 C11ORF54 SP1 STK40 POM121 LONP1 XRCC2 FANK1 HSPA1B HSPA1A PPP1R10 SRA1 ZNF432 GMCL1 RGS2 ETV3 HSPA2 DNAJB9 DNAJB1 ASCC1 CIART BNIP3 ARL6IP4 IPPK NEDD4L RORA HSP90AA1 TRMT6 NR4A3 NR4A1 SNAI1 EGLN3 USP37 ANP32A ESCO1 SMYD2 METTL21A NOCT DDIT3 MAFF TRIM33 PPME1 |
| 0.00090047 | 49 | Nucleoplasm part | AFF4 EED FBL KDM4C KDM6B MED10 SAP130 KANSL1L POLR2H SAP30 HDAC3 ZNF407 ATP6V0A1 USP28 PIAS2 ALKBH5 POLI IMPAD1 BNIP3L HBP1 GADD45A STK35 ZBTB1 THOC6 USPL1 BHLHE40 PIP5K1A EAF1 NPAT LSM11 CHTOP YEATS2 RAB8B MAPK7 POLR3D ING2 MLLT3 NMNAT1 C11ORF54 HSPA1B HSPA1A PPP1R10 ETV3 THAP1 ASCC1 EIF4A3 CIART ARL6IP4 PCF11 |
| 0.006030162 | 3 | Transcription factor AP-1 complex | JUNB JUN DDIT3 |
| 0.018260045 | 34 | Nuclear body | FBL ATP6V0A1 USP28 PIAS2 ALKBH5 POLI IMPAD1 BNIP3L HBP1 GADD45A STK35 ZBTB1 THOC6 USPL1 BHLHE40 SAP130 PIP5K1A EAF1 NPAT LSM11 CHTOP RAB8B MAPK7 POLR3D NMNAT1 C11ORF54 HSPA1B HSPA1A PPP1R10 THAP1 ASCC1 EIF4A3 CIART ARL6IP4 |
| 0.021715976 | 2 | CHOP-ATF3 complex | DDIT3 ATF3 |
| 0.029594035 | 4 | Integral component of mitochondrial outer membrane | MGARP FUNDC2 ABCB6 BNIP3 |
| 0.03197158 | 4 | Intrinsic component of mitochondrial outer membrane | MGARP FUNDC2 ABCB6 BNIP3 |
| 0.044981646 | 2 | SREBP-SCAP-Insig complex | INSIG2 INSIG1 |